Defects in T-cell-mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector-mediated gene transfer into repopulating hematopoietic cells.
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Hematopoietic stem cell gene therapy:assessing the relevance of preclinical modelsTransduction of human primitive repopulating hematopoietic cells with lentiviral vectors pseudotyped with various envelope proteins.Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models.Foamy virus vector-mediated gene correction of a mouse model of Wiskott-Aldrich syndrome.Gene transfer into hematopoietic stem cells as treatment for primary immunodeficiency diseases.B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.Retroviral vectors: new applications for an old tool.Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome.Survival of the fittest: in vivo selection and stem cell gene therapyWiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells.WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiencyWiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activationWiskott-Aldrich syndrome protein--dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes.Signal Integration during T Lymphocyte Activation and Function: Lessons from the Wiskott-Aldrich Syndrome.Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome.Lentiviral vectors targeting WASp expression to hematopoietic cells, efficiently transduce and correct cells from WAS patients.Current understanding of the Wiskott-Aldrich syndrome and prospects for gene therapy.Gene therapy in primary immunodeficiencies.A lentiviral vector encoding the human Wiskott-Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice.
P2860
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P2860
Defects in T-cell-mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector-mediated gene transfer into repopulating hematopoietic cells.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Defects in T-cell-mediated imm ...... opulating hematopoietic cells.
@ast
Defects in T-cell-mediated imm ...... opulating hematopoietic cells.
@en
type
label
Defects in T-cell-mediated imm ...... opulating hematopoietic cells.
@ast
Defects in T-cell-mediated imm ...... opulating hematopoietic cells.
@en
prefLabel
Defects in T-cell-mediated imm ...... opulating hematopoietic cells.
@ast
Defects in T-cell-mediated imm ...... opulating hematopoietic cells.
@en
P2093
P1433
P1476
Defects in T-cell-mediated imm ...... opulating hematopoietic cells.
@en
P2093
Arthur W Nienhuis
Deo Kumar Srivastava
Haiyan Liu
John M Cunningham
Samita Andreansky
Ted S Strom
P304
P356
10.1182/BLOOD-2002-11-3489
P407
P577
2003-07-10T00:00:00Z