Survival of the fittest: in vivo selection and stem cell gene therapy
about
Combinatorial RNA-based gene therapy for the treatment of HIV/AIDSPhenotypic evolutionary models in stem cell biology: replacement, quiescence, and variabilityComputational models of HIV-1 resistance to gene therapy elucidate therapy design principlesEfficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma.Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of hypoxanthine-Guanine phosphoribosyltransferase short hairpin RNA confers chemoprotection against 6-thioguanine cytotoxicity.Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrowLong-term regulation of genetically modified primary hematopoietic cells in dogs.Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.In vivo selection of autologous MGMT gene-modified cells following reduced-intensity conditioning with BCNU and temozolomide in the dog modelLive and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotectionInterfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection.Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipientsIn vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.Hematopoietic stem cell expansion and gene therapy.Cytogenetic instability of dental pulp stem cell lines.The leak stops here: platelets as delivery vehicles for coagulation factorsDeoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy.A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice.
P2860
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P2860
Survival of the fittest: in vivo selection and stem cell gene therapy
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
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2005年學術文章
@zh-hant
name
Survival of the fittest: in vivo selection and stem cell gene therapy
@ast
Survival of the fittest: in vivo selection and stem cell gene therapy
@en
type
label
Survival of the fittest: in vivo selection and stem cell gene therapy
@ast
Survival of the fittest: in vivo selection and stem cell gene therapy
@en
prefLabel
Survival of the fittest: in vivo selection and stem cell gene therapy
@ast
Survival of the fittest: in vivo selection and stem cell gene therapy
@en
P2860
P1433
P1476
Survival of the fittest: in vivo selection and stem cell gene therapy
@en
P2093
Brian C Beard
Hans-Peter Kiem
P2860
P304
P356
10.1182/BLOOD-2005-06-2335
P407
P50
P577
2005-11-03T00:00:00Z