Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling.
about
Engineered IgG1-Fc--one fragment to bind them allApplications of Yeast Surface Display for Protein EngineeringMicrobial enzymes: tools for biotechnological processesCells and cell lysates: a direct approach for engineering antibodies against membrane proteins using yeast surface displayA potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainA De Novo Protein Binding Pair By Computational Design and Directed EvolutionMolecular Basis of a Million-Fold Affinity Maturation Process in a Protein–Protein InteractionTeaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 ScaffoldComputational Design of a Protein-Based Enzyme InhibitorA current perspective on applications of macrocyclic-peptide-based high-affinity ligandsArtificial affinity proteins as ligands of immunoglobulinsDirected Evolution of a Highly Specific FN3 Monobody to the SH3 Domain of Human Lyn Tyrosine Kinase.Isolation of monobodies that bind specifically to the SH3 domain of the Fyn tyrosine protein kinase.Ultrasound Molecular Imaging of the Breast Cancer Neovasculature using Engineered Fibronectin Scaffold Ligands: A Novel Class of Targeted Contrast Ultrasound AgentBispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn.Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display.Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodiesThe full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffoldStability and CDR composition biases enrich binder functionality landscapes.Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging.PCRless library mutagenesis via oligonucleotide recombination in yeastNextGen protein design.Adnectins: engineered target-binding protein therapeuticsScaffoldSeq: Software for characterization of directed evolution populations.Shortened engineered human antibody CH2 domains: increased stability and binding to the human neonatal Fc receptor.Human monoclonal antibody fragments binding to insulin-like growth factors I and II with picomolar affinity.Bacterial display in combinatorial protein engineering.Epidermal growth factor receptor downregulation by small heterodimeric binding proteinsFoundations for the design and implementation of synthetic genetic circuits.Engineered Fc based antibody domains and fragments as novel scaffolds.Optimization of ordered plasmid assembly by gap repair in Saccharomyces cerevisiae.Strategies to control the binding mode of de novo designed protein interactions.Peptide aptamers: development and applications.The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold InteractionsConvergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moietiesEngineered antibody variable and constant domains as therapeutic candidates.Directed evolution of a yeast-displayed HIV-1 SOSIP gp140 spike protein toward improved expression and affinity for conformational antibodies.Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions.
P2860
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P2860
Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.
@ast
Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.
@en
type
label
Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.
@ast
Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.
@en
prefLabel
Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.
@ast
Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.
@en
P2093
P2860
P1476
Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.
@en
P2093
Atul Kapila
Benjamin J Hackel
K Dane Wittrup
P2860
P304
P356
10.1016/J.JMB.2008.06.051
P407
P577
2008-06-24T00:00:00Z