Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS - Wikidata - awgldk - TriplyDB

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS

http://www.wikidata.org/entity/Q33358054

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APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.Dysregulated axonal RNA translation in amyotrophic lateral sclerosis A comprehensive review of amyotrophic lateral sclerosis Oxidative Stress in Neurodegenerative Diseases Free radicals: properties, sources, targets, and their implication in various diseases Electromagnetic fields, oxidative stress, and neurodegeneration Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis.Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease.DNA-triggered aggregation of copper, zinc superoxide dismutase in the presence of ascorbate.Cardiac Cell Senescence and Redox Signaling.Mechanisms, models and biomarkers in amyotrophic lateral sclerosis Oxidative damage to RNA: mechanisms, consequences, and diseases.Effects of axon degeneration on oligodendrocyte lineage cells: dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis.An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe Cupric ions induce the oxidation and trigger the aggregation of human superoxide dismutase 1 Experimental model for ELF-EMF exposure: Concern for human health.Effect of CCS on the accumulation of FALS SOD1 mutant-containing aggregates and on mitochondrial translocation of SOD1 mutants: implication of a free radical hypothesis RNA oxidation catalyzed by cytochrome c leads to its depurination and cross-linking, which may facilitate cytochrome c release from mitochondria.Oxidative stress in neurodegeneration Aging--RNA in development and disease.Short-lived recombinant adeno-associated virus transgene expression in dystrophic muscle is associated with oxidative damage to transgene mRNA.Products of lipid, protein and RNA oxidation as signals and regulators of gene expression in plants Role of Oxidative RNA Damage in Chronic-Degenerative Diseases.The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons.The effect of RNA base lesions on mRNA translation.RNAseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation as a Major Abnormality in ALS Spinal Cord.Characterization of RNA damage under oxidative stress in Escherichia coli.Redox processes in neurodegenerative disease involving reactive oxygen species Role of protein and mRNA oxidation in seed dormancy and germination Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.RNA processing defects associated with diseases of the motor neuron The wobbler mouse, an ALS animal model.Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis.NADPH oxidase in brain injury and neurodegenerative disorders Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells.Battle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells.The role of RNA processing in the pathogenesis of motor neuron degeneration.SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments.

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Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS

http://www.wikidata.org/entity/Q33358054

description

2008 nî lūn-bûn

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2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2008 թվականի օգոստոսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Messenger RNA oxidation occurs ...... tor neuron degeneration in ALS

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Messenger RNA oxidation occurs ...... tor neuron degeneration in ALS

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type

label

Messenger RNA oxidation occurs ...... tor neuron degeneration in ALS

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Messenger RNA oxidation occurs ...... tor neuron degeneration in ALS

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Messenger RNA oxidation occurs ...... tor neuron degeneration in ALS

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Messenger RNA oxidation occurs ...... tor neuron degeneration in ALS

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JOURNAL.PONE.0002849

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Messenger RNA oxidation occurs ...... tor neuron degeneration in ALS

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Chien-Liang Glenn Lin

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David R Borchelt

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Guilian Tian

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Hristelina Ilieva

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Jeffrey D Rothstein

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Philip C Wong

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Qiongman Kong

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Xiu Shan

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Yueming Chang

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P2860

A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.

Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

ALS: a disease of motor neurons and their nonneuronal neighbors

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.

High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study.

Vitamin E intake and risk of amyotrophic lateral sclerosis.

Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target.

Neuronal intermediate filaments and ALS: a new look at an old question.

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e2849

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10.1371/JOURNAL.PONE.0002849

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8

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3

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Don W Cleveland

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2008-08-06T00:00:00Z

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23151725

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18682740

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amyotrophic lateral sclerosis

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2481395

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