Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity - Wikidata - awgldk - TriplyDB

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

http://www.wikidata.org/entity/Q33373484

about

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase Structural Maturation of HIV-1 Reverse Transcriptase-A Metamorphic Solution to Genomic Instability The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes Virtual screening models for prediction of HIV-1 RT associated RNase H inhibition Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C.High-throughput screening of a diversity collection using biodefense category A and B priority pathogens Novel approaches to inhibiting HIV-1 replication.Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies The biology and synthesis of α-hydroxytropolones.Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Identification of small-molecule inhibitors of the ribonuclease H2 enzyme.HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity.Interaction of HIV-1 reverse transcriptase ribonuclease H with an acylhydrazone inhibitor.Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors.The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets.Structural basis of the allosteric inhibitor interaction on the HIV-1 reverse transcriptase RNase H domain.Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise.Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.Examining the role of the HIV-1 reverse transcriptase p51 subunit in positioning and hydrolysis of RNA/DNA hybrids Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase."Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.Purification and enzymatic characterization of the hepatitis B virus ribonuclease H, a new target for antiviral inhibitors.HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.Binding free energy based structural dynamics analysis of HIV-1 RT RNase H-inhibitor complexes.From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

P2860

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P2860

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

http://www.wikidata.org/entity/Q33373484

description

2008 nî lūn-bûn

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2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Vinylogous ureas as a novel cl ...... ciated ribonuclease H activity

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Vinylogous ureas as a novel cl ...... ciated ribonuclease H activity

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Vinylogous ureas as a novel cl ...... ciated ribonuclease H activity

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Vinylogous ureas as a novel cl ...... ciated ribonuclease H activity

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Vinylogous ureas as a novel cl ...... ciated ribonuclease H activity

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ACS Chemical Biology

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Vinylogous ureas as a novel cl ...... ciated ribonuclease H activity

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P2093

Alun Bermingham

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Barry R O'Keefe

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Hsiu-Fang Lee

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Jennifer T Miller

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Marion K Bona

http://www.w3.org/2001/XMLSchema#string

Maryam Ehteshami

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Matthias Götte

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Michaela Wendeler

http://www.w3.org/2001/XMLSchema#string

Noel S Baichoo

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Oleg Chertov

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P2860

Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

Expanding the genetic code

A genetically encoded fluorescent amino acid

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent

A capillary electrophoretic assay for ribonuclease H activity.

A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity.

P304

635-644

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scholarly article

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10.1021/CB8001039

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10

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P478

3

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Mamuka Kvaratskhelia

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2008-10-03T00:00:00Z

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23296220

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18831589

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2941776

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