Sequence determinants of protein aggregation in human VH domains.
about
Recombinant antibody production evolves into multiple options aimed at yielding reagents suitable for application-specific needsStability engineering of the human antibody repertoireGeneral strategy for the generation of human antibody variable domains with increased aggregation resistanceSuppressing mutation-induced protein aggregation in mammalian cells by mutating residues significantly displaced upon the original mutationCis-suppression to arrest protein aggregation in mammalian cells.Positive selection differs between protein secondary structure elements in DrosophilaPhysico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm.Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies.A novel heavy domain antibody library with functionally optimized complementarity determining regions.Isolation and optimization for affinity and biophysical characteristics of anti-CCL17 antibodies from the VH1-69 germline gene.Stress selections on domain antibodies: 'what doesn't kill you makes you stronger'.Engineered Autonomous Human Variable DomainsNanoyeast and Other Cell Envelope Compositions for Protein Studies and Biosensor Applications.De novo design of a biologically active amyloid.Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies.Molecular dynamics simulations and docking enable to explore the biophysical factors controlling the yields of engineered nanobodies.Engineered Antibody Fragments for Immunodiagnosis of Papaya ringspot virus.Degradation of C-terminal tag sequences on domain antibodies purified from E. coli supernatant.In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development.Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions.Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries.Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.Expression of high-affinity human antibody fragments in bacteria.
P2860
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P2860
Sequence determinants of protein aggregation in human VH domains.
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Sequence determinants of protein aggregation in human VH domains.
@ast
Sequence determinants of protein aggregation in human VH domains.
@en
type
label
Sequence determinants of protein aggregation in human VH domains.
@ast
Sequence determinants of protein aggregation in human VH domains.
@en
prefLabel
Sequence determinants of protein aggregation in human VH domains.
@ast
Sequence determinants of protein aggregation in human VH domains.
@en
P2860
P356
P1476
Sequence determinants of protein aggregation in human VH domains.
@en
P2093
Kip Dudgeon
Kristoffer Famm
P2860
P304
P356
10.1093/PROTEIN/GZN059
P577
2008-10-28T00:00:00Z