Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.
about
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.The contribution of mouse models to the understanding of constitutional thrombocytopeniaNon-muscle myosin II in disease: mechanisms and therapeutic opportunitiesNon-muscle myosin II takes centre stage in cell adhesion and migrationIntrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias.Inherited platelet disorders: a clinical approach to diagnosis and management.Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.Inherited thrombocytopenias: an approach to diagnosis and management.Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3)The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopeniaA Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.The Myosin II Inhibitor, Blebbistatin, Ameliorates FeCl3-induced Arterial Thrombosis via the GSK3β-NF-κB Pathway.Carboxyl-terminal-dependent recruitment of nonmuscle myosin II to megakaryocyte contractile ring during polyploidization.Practical murine hematopathology: a comparative review and implications for research.Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis.Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates.Mouse models of diseases of megakaryocyte and platelet homeostasis.What Is the Biological and Clinical Relevance of Fibrin?Distinct functional effects for dynamin 3 during megakaryocytopoiesis.Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA (MYH9 protein) in human podocytes.Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes.SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion.The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia
P2860
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P2860
Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Abnormal megakaryocyte morphol ...... -restricted MYH9 inactivation.
@ast
Abnormal megakaryocyte morphol ...... -restricted MYH9 inactivation.
@en
type
label
Abnormal megakaryocyte morphol ...... -restricted MYH9 inactivation.
@ast
Abnormal megakaryocyte morphol ...... -restricted MYH9 inactivation.
@en
prefLabel
Abnormal megakaryocyte morphol ...... -restricted MYH9 inactivation.
@ast
Abnormal megakaryocyte morphol ...... -restricted MYH9 inactivation.
@en
P2093
P50
P1433
P1476
Abnormal megakaryocyte morphol ...... e-restricted MYH9 inactivation
@en
P2093
Catherine Strassel
Christian Gachet
Jean-Pierre Cazenave
Monique Freund
P304
P356
10.1182/BLOOD-2008-06-164061
P407
P577
2008-11-04T00:00:00Z