about
The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is preventedA PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.Synthesis of GPIb beta with novel transmembrane and cytoplasmic sequences in a Bernard-Soulier patient resulting in GPIb-defective signaling in CHO cells.Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets.Targeting platelet GPIbβ reduces platelet adhesion, GPIb signaling and thrombin generation and prevents arterial thrombosis.Respective contributions of single and compound granule fusion to secretion by activated platelets.Biogenesis of the demarcation membrane system (DMS) in megakaryocytes.Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting.Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes.Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ibβ function.Aryl hydrocarbon receptor-dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets.The platelet glycoprotein GPIbbeta intracellular domain participates in von Willebrand factor induced-filopodia formation independently of the Ser 166 phosphorylation site.Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice.Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.Dehydration of blood platelets by zeodration: in vitro characterization and hemostatic properties in vivo.Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide.The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.Microtubule plus-end tracking Adenopolyposis Coli negatively regulates proplatelet formationAn essential role for α4A-tubulin in platelet biogenesisArterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterizationCytochemical distribution of cyclic AMP-dependent 3',5'-nucleotide phosphodiesterase in the rat myocardiumIsoprenaline induces endothelium-independent relaxation and accumulation of cyclic nucleotides in the rat aortaDesensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptorsSpecies differences in localization of cardiac cAMP-phosphodiesterase activity: a cytochemical studyDifferential involvement of the P2Y1 and P2YT receptors in the morphological changes of platelet aggregationThe P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrelFurther evidence that fibrillar collagen is unable to promote platelet shape change and aggregation in the absence of secondary agonistsHirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitorsCharacterization of megakaryocyte development in the native bone marrow environment
P50
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P50
description
researcher
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wetenschapper
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A Eckly
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A Eckly
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type
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A Eckly
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A Eckly
@nl
prefLabel
A Eckly
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A Eckly
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P106
P31
P496
0000-0001-9620-4961