Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.

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http://www.wikidata.org/entity/Q33391298
The contribution of mouse models to the understanding of constitutional thrombocytopeniaMyosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.The value of a native milieu: mutated non-muscle myosin IIA does lead to thrombocytopenia.Inherited platelet disorders: a clinical approach to diagnosis and management.The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopeniaThe role of vertebrate nonmuscle Myosin II in development and human disease.Cell-autonomous function of Runx1 transcriptionally regulates mouse megakaryocytic maturation.Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis.Tense your megas! Structural rigidity is keyMegakaryocyte Polyploidization and Proplatelet Formation in Low-Attachment Conditions.Distinct functional effects for dynamin 3 during megakaryocytopoiesis.Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes.A new path to platelet production through matrix sensing.
P2860

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.

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http://www.wikidata.org/entity/Q33391298
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2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Proplatelet formation deficit ...... topenia in Myh9 knockout mice.
@ast
Proplatelet formation deficit ...... topenia in Myh9 knockout mice.
@en
type
label
Proplatelet formation deficit ...... topenia in Myh9 knockout mice.
@ast
Proplatelet formation deficit ...... topenia in Myh9 knockout mice.
@en
prefLabel
Proplatelet formation deficit ...... topenia in Myh9 knockout mice.
@ast
Proplatelet formation deficit ...... topenia in Myh9 knockout mice.
@en
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P356
P1433
P1476
Proplatelet formation deficit ...... ytopenia in Myh9 knockout mice
@en
P2093
P304
P31
P356
10.1111/J.1538-7836.2010.04009.X
P433
P478
P50
P577
P5875
P698
P921