Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms
about
Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapyThe mechanism of necroptosis in normal and cancer cellsFusion toxin BLyS-gelonin inhibits growth of malignant human B cell lines in vitro and in vivoAutophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibitionTargeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell typeStaurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells.Shikonin kills glioma cells through necroptosis mediated by RIP-1Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue.High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acidNecroptosis: biochemical, physiological and pathological aspects.The role of necroptosis, an alternative form of cell death, in cancer therapy.Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis.Interferon-β-armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells.Targeting head and neck squamous cell carcinoma using a novel fusion toxin-diphtheria toxin/HN-1.Ubenimex enhances the radiosensitivity of renal cell carcinoma cells by inducing autophagic cell death.Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells.Shikonin induces apoptosis and necroptosis in pancreatic cancer via regulating the expression of RIP1/RIP3 and synergizes the activity of gemcitabine.Targeting of phospho-eIF4E by homoharringtonine eradicates a distinct subset of human acute myeloid leukemia.Ubenimex, an APN inhibitor, could serve as an anti‑tumor drug in RT112 and 5637 cells by operating in an Akt‑associated manner.
P2860
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P2860
Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Acute myeloid leukemia-targete ...... d necroptotic death mechanisms
@ast
Acute myeloid leukemia-targete ...... d necroptotic death mechanisms
@en
type
label
Acute myeloid leukemia-targete ...... d necroptotic death mechanisms
@ast
Acute myeloid leukemia-targete ...... d necroptotic death mechanisms
@en
prefLabel
Acute myeloid leukemia-targete ...... d necroptotic death mechanisms
@ast
Acute myeloid leukemia-targete ...... d necroptotic death mechanisms
@en
P2860
P1433
P1476
Acute myeloid leukemia-targete ...... d necroptotic death mechanisms
@en
P2093
Andrew Thorburn
Henrick Horita
P2860
P356
10.1371/JOURNAL.PONE.0003909
P407
P577
2008-12-11T00:00:00Z