Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. - Wikidata - awgldk - TriplyDB

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.

http://www.wikidata.org/entity/Q33397149

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Mitochondria, cholesterol and cancer cell metabolism Role of autophagy in megakaryocyte differentiation and platelet formation Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets Linkage between the mechanisms of thrombocytopenia and thrombopoiesis Transcription factors in late megakaryopoiesis and related platelet disorders Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation A megakaryocyte with no platelets: anti-platelet antibodies, apoptosis, and platelet production.Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside.Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.The role of apoptosis in megakaryocytes and platelets.Lessons in platelet production from inherited thrombocytopenias.Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation.Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan.Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.Impaired proplatelet formation in immune thrombocytopenia: a novel mechanism contributing to decreased platelet count.Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia.The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.BCL-2 is dispensable for thrombopoiesis and platelet survival Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c Manipulating megakaryocytes to manufacture platelets ex vivo.Novel mechanisms of platelet clearance and thrombopoietin regulation.P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.Inherited thrombocytopenia: novel insights into megakaryocyte maturation, proplatelet formation and platelet lifespan.Regulation of platelet lifespan by apoptosis.Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia.Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling.Investigation of platelet apoptosis in adult patients with chronic immune thrombocytopenia.Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors.Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells.MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication Actin inhibition increases megakaryocyte proplatelet formation through an apoptosis-dependent mechanism.A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.Regulating billions of blood platelets: glycans and beyond.PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake.Alzheimer disease and platelets: how's that relevant.

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P2860

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.

http://www.wikidata.org/entity/Q33397149

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Megakaryocytes possess a funct ...... survive and produce platelets.

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Megakaryocytes possess a funct ...... survive and produce platelets.

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Megakaryocytes possess a funct ...... survive and produce platelets.

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Journal of Experimental Medicine

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Megakaryocytes possess a funct ...... survive and produce platelets.

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Chloé James

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David C S Huang

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Elizabeth A Kruse

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Katya J Henley

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Lorraine A O'Reilly

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Mark R Dowling

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Marlyse A Debrincat

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Paquita Nurden

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Rachael M Lane

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P2860

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis.

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

No death without life: vital functions of apoptotic effectors

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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2017-2031

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10.1084/JEM.20110750

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10

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208

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Andrew W Roberts

Michael J. White

Benjamin T. Kile

Kelly L. Rogers

Emma C Josefsson

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2011-09-12T00:00:00Z

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51631784

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21911424

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3182050

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