Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
about
MiR-221 and miR-222 target PUMA to induce cell survival in glioblastomaTwo independent positive feedbacks and bistability in the Bcl-2 apoptotic switchUse of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilizationActive Bax and Bak are functional holinsNoxa is necessary for hydrogen peroxide-induced caspase-dependent cell deathBcl-x(L) retrotranslocates Bax from the mitochondria into the cytosolProtection from rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signalingHuman nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domainHeterodimerization of BAK and MCL-1 activated by detergent micellesBH3 domains other than Bim and Bid can directly activate Bax/BakStructural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xLSynthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer modelsERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xLBimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosisMcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell linesA novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathwaysA short Nur77-derived peptide converts Bcl-2 from a protector to a killerBcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpointsMutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosisIdentification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylationThe Bcl-2 apoptotic switch in cancer development and therapyPUMA, a potent killer with or without p53Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapySmall-molecule Bcl-2 antagonists as targeted therapy in oncologyApolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell deathBH3 mimetics to improve cancer therapy; mechanisms and examplesPotential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?Regulation of Bim in Health and DiseaseTargeting BCL2-Proteins for the Treatment of Solid TumoursAnti-apoptotic BCL-2 family proteins in acute neural injuryTargeting the Bcl-2 family for cancer therapyBAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreBH3 peptides induce mitochondrial fission and cell death independent of BAX/BAKA novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradationStructural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68BAX activation is initiated at a novel interaction siteConformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind LigandsDeterminants of BH3 Binding Specificity for Mcl-1 versus Bcl-xLEvidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX
P2860
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P2860
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@ast
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@en
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@en-gb
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@nl
type
label
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@ast
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@en
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@en-gb
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@nl
prefLabel
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@ast
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@en
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@en-gb
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@nl
P2093
P50
P921
P3181
P356
P1433
P1476
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
@en
P2093
David C S Huang
Helen Ierino
Jamie I Fletcher
Jerry M Adams
Peter E Czabotar
Simon N Willis
W Douglas Fairlie
P3181
P356
10.1126/SCIENCE.1133289
P407
P577
2007-02-09T00:00:00Z