A phase I first-in-human study with tefinostat - a monocyte/macrophage targeted histone deacetylase inhibitor - in patients with advanced haematological malignancies.
about
Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseasesAn immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts.Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.Emerging approaches for histone deacetylase inhibitor drug discovery.The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias.Synergistic antitumor effects of the combined treatment with an HDAC6 inhibitor and a COX-2 inhibitor through activation of PTEN.
P2860
A phase I first-in-human study with tefinostat - a monocyte/macrophage targeted histone deacetylase inhibitor - in patients with advanced haematological malignancies.
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
A phase I first-in-human study ...... d haematological malignancies.
@ast
A phase I first-in-human study ...... d haematological malignancies.
@en
type
label
A phase I first-in-human study ...... d haematological malignancies.
@ast
A phase I first-in-human study ...... d haematological malignancies.
@en
prefLabel
A phase I first-in-human study ...... d haematological malignancies.
@ast
A phase I first-in-human study ...... d haematological malignancies.
@en
P2093
P2860
P356
P1476
A phase I first-in-human study ...... d haematological malignancies.
@en
P2093
Alan H Davidson
Arjan A Van de Loosdrecht
Dimitri Breems
Gert J Ossenkoppele
Graham Wells
Leon Hooftman
Lindsay Bawden
Lindsey Needham
Martin Toal
Norbert Vey
P2860
P304
P356
10.1111/BJH.12359
P407
P577
2013-05-07T00:00:00Z