Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
about
Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseasesNew and emerging HDAC inhibitors for cancer treatmentHistone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophagesA phase I first-in-human study with tefinostat - a monocyte/macrophage targeted histone deacetylase inhibitor - in patients with advanced haematological malignancies.The therapeutic potential of class I selective histone deacetylase inhibitors in ovarian cancerSuberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants.Histone/protein deacetylases and T-cell immune responsesComparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1Targeting class I histone deacetylases in cancer therapy.Macrophages associated with tumors as potential targets and therapeutic intermediates.Macrophages: central regulators of iron balance.Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.The evolution of our understanding of macrophages and translation of findings toward the clinic.Emerging approaches for histone deacetylase inhibitor drug discovery.Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors.Tumor-associated myeloid cells: new understandings on their metabolic regulation and their influence in cancer immunotherapy.
P2860
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P2860
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
@en
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
@nl
type
label
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
@en
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
@nl
prefLabel
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
@en
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
@nl
P2093
P356
P1476
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs
@en
P2093
Alan H Davidson
Alan H Drummond
Alastair Donald
Andrew Belfield
David Krige
David Moffat
Deborah H Brotherton
Elisabeth A Bone
Francesca A Day
Graham M A Wells
P304
P356
10.1124/JPET.111.183640
P407
P577
2011-07-21T00:00:00Z