Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. - Wikidata - awgldk - TriplyDB

Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.

Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.

http://www.wikidata.org/entity/Q33412120

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Recurrent DNMT3A mutations in patients with myelodysplastic syndromes Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice NPM1 deletion is associated with gross chromosomal rearrangements in leukemia The clinical safety of lenalidomide in multiple myeloma and myelodysplastic syndromes.The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.Genetic deletions in AML and MDS.Genomic alterations in abnormal neutrophils isolated from adult patients with systemic lupus erythematosus Genetic pathways leading to therapy-related myeloid neoplasms.Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells.Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.Clonal architecture of secondary acute myeloid leukemia.Treatment-related myelodysplastic syndrome: molecular characteristics and therapy Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.Molecular pathophysiology of myelodysplastic syndromes.Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.Therapy-related myelodysplastic syndrome: models and genetics.Unraveling the molecular pathophysiology of myelodysplastic syndromes.Pleiotropic mechanisms of action of lenalidomide efficacy in del(5q) myelodysplastic syndromes.Detection of copy number alterations in acute myeloid leukemia and myelodysplastic syndromes.Standardizing the initial evaluation for myelodysplastic syndromes.Comprehensive array CGH of normal karyotype myelodysplastic syndromes reveals hidden recurrent and individual genomic copy number alterations with prognostic relevance.snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma.KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia.Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia

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Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.

http://www.wikidata.org/entity/Q33412120

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Integrated genomic analysis im ...... lastic syndromes pathogenesis.

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Integrated genomic analysis im ...... lastic syndromes pathogenesis.

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Integrated genomic analysis im ...... lastic syndromes pathogenesis.

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Jin Shao

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John L Frater

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Mark A Walshauser

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Matthew J Walter

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Michelle A Payton

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Mike G Martin

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Richard A Walgren

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Ryan S Monahan

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Yumi Kasai

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P2860

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases

Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)

Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

Circular binary segmentation for the analysis of array-based DNA copy number data

wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data

Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31.

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e4583

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Timothy A. Graubert

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24038240

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19240791

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haploinsufficiency

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