Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.
about
Evaluation of cytotoxicity and genotoxicity of Inula viscosa leaf extracts with Allium test.The vanishing zero revisited: thresholds in the age of genomics.Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships.Comparative evaluation of 11 in silico models for the prediction of small molecule mutagenicity: role of steric hindrance and electron-withdrawing groups.Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update.Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens.Reproductive toxicants have a threshold of adversity.Non-clinical toxicological considerations for pharmaceutical salt selection.The holy grail in genetic toxicology: follow-up approaches for positive results in the Ames assay.Defining EMS and ENU dose-response relationships using the Pig-a mutation assay in ratsSetting Occupational Exposure Limits for Genotoxic Substances in the Pharmaceutical Industry.Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate.Sublinear response in lacZ mutant frequency of Muta™ Mouse spermatogonial stem cells after low dose subchronic exposure to N-ethyl-N-nitrosourea.Refractory status epilepticus, serious rhabdomyolysis, acute liver injury, and pancytopenia after a massive intake of ethyl methanesulfonate: a case report.Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay.Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement.New approaches to advance the use of genetic toxicology analyses for human health risk assessment
P2860
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P2860
Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Ethyl methanesulfonate toxicit ...... reshold data for genotoxicity.
@ast
Ethyl methanesulfonate toxicit ...... reshold data for genotoxicity.
@en
type
label
Ethyl methanesulfonate toxicit ...... reshold data for genotoxicity.
@ast
Ethyl methanesulfonate toxicit ...... reshold data for genotoxicity.
@en
prefLabel
Ethyl methanesulfonate toxicit ...... reshold data for genotoxicity.
@ast
Ethyl methanesulfonate toxicit ...... reshold data for genotoxicity.
@en
P2093
P1433
P1476
Ethyl methanesulfonate toxicit ...... reshold data for genotoxicity.
@en
P2093
Elmar Gocke
Lutz Müller
Thierry Lavé
Thomas Pfister
P304
P356
10.1016/J.TOXLET.2009.04.003
P577
2009-04-10T00:00:00Z