Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells

Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells

Item
http://www.wikidata.org/entity/Q33453188
Computational Approaches for the Discovery of Human Proteasome Inhibitors: An OverviewSynthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitorsThe Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membraneDiscovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent mannerNew molecular targeted therapies for advanced non-small-cell lung cancer.MG132 inhibition of proteasome blocks apoptosis induced by severe DNA damage.Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 InteractionSubstituted quinolines as noncovalent proteasome inhibitors.Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity.Proteasome inhibitors: an expanding army attacking a unique target.Selective anticancer copper(II)-mixed ligand complexes: targeting of ROS and proteasomes.Depletion of K-Ras promotes proteasome degradation of survivinFoxM1 knockdown sensitizes human cancer cells to proteasome inhibitor-induced apoptosis but not to autophagy.Selectively killing transformed cells through proteasome inhibition.Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing.
P2860

Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells

Item
http://www.wikidata.org/entity/Q33453188
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Discovery of a novel proteasom ...... lls over non-transformed cells
@ast
Discovery of a novel proteasom ...... lls over non-transformed cells
@en
type
label
Discovery of a novel proteasom ...... lls over non-transformed cells
@ast
Discovery of a novel proteasom ...... lls over non-transformed cells
@en
prefLabel
Discovery of a novel proteasom ...... lls over non-transformed cells
@ast
Discovery of a novel proteasom ...... lls over non-transformed cells
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Discovery of a novel proteasom ...... lls over non-transformed cells
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P932