Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents. - Wikidata - awgldk - TriplyDB

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

http://www.wikidata.org/entity/Q33474088

about

Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer Inhibition of heat-shock protein 90 reduces Ebola virus replication Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design Heat-shock protein 90 promotes nuclear transport of herpes simplex virus 1 capsid protein by interacting with acetylated tubulin Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.Solid-phase parallel synthesis of a tetrahydroindazolone library containing three unique core skeletons.Probing the probes: fitness factors for small molecule tools.Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation Thermodynamics of aryl-dihydroxyphenyl-thiadiazole binding to human Hsp90 Macrocyclic drugs and synthetic methodologies toward macrocycles Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes.Design, synthesis, and evaluation of small molecule Hsp90 probes.Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.A systematic protocol for the characterization of Hsp90 modulators.HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.Hsp90, an unlikely ally in the war on cancer.Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases.Reverse the Resistance to PARP Inhibitors.Current status of agents active against the T315I chronic myeloid leukemia phenotype.Macrocycles in new drug discovery.Heat-shock protein 90 (Hsp90) as anticancer target for drug discovery: an ample computational perspective.Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors.Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells.Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions.Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime.Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives.A highly selective Hsp90 affinity chromatography resin with a cleavable linker.2-Acyl-dimedones as UV-active protective agents for chiral amino acids: enantiomer separations of the derivatives on chiral anion exchangers.Identification of Hsp90 inhibitors with anti-Plasmodium activity.Synthesis and Activity of a New Series of Antileishmanial Agents.Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer.Metabolism elucidation of BJ-B11 (a heat shock protein 90 inhibitor) by human liver microsomes: identification of main contributing enzymes.Metabolite elucidation of the Hsp90 inhibitor SNX-2112 using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS).P-glycoprotein (P-gp)-mediated efflux limits intestinal absorption of the Hsp90 inhibitor SNX-2112 in rats One-pot synthesis of polysubstituted 3-acylpyrroles by cooperative catalysis Synthesis of 5,6-dihydro-4H -benzo[d ]isoxazol-7-one and 5,6-dihydro-4H -isoxazolo[5,4-c ]pyridin-7-one Derivatives as Potential Hsp90 Inhibitors

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P2860

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

http://www.wikidata.org/entity/Q33474088

description

2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Discovery of novel 2-aminobenz ...... rally active antitumor agents.

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Discovery of novel 2-aminobenz ...... rally active antitumor agents.

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type

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Discovery of novel 2-aminobenz ...... rally active antitumor agents.

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Discovery of novel 2-aminobenz ...... rally active antitumor agents.

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prefLabel

Discovery of novel 2-aminobenz ...... rally active antitumor agents.

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Discovery of novel 2-aminobenz ...... rally active antitumor agents.

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Journal of Medicinal Chemistry

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Discovery of novel 2-aminobenz ...... rally active antitumor agents.

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P2093

Amy F Barabasz

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Andy J Ommen

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Angela R Woodward

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Anisa Scott

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Bert Pronk

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Briana E Foley

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Christopher J Markworth

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Emilie D Smith

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Gunnar J Hanson

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James M Veal

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4288-4305

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scholarly article

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10.1021/JM900230J

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14

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52

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2009-07-01T00:00:00Z

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19552433

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