Probing the probes: fitness factors for small molecule tools.
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Open access chemical probes for epigenetic targetsDiversity-oriented synthetic strategies applied to cancer chemical biology and drug discoveryChemical probes of histone lysine methyltransferasesAdvancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesA Cell Biologist's Field Guide to Aurora Kinase InhibitorsAurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.Structure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)PubChem as a public resource for drug discoveryRational methods for the selection of diverse screening compoundsContributions of academic laboratories to the discovery and development of chemical biology toolsMechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signallingIdentification of a small molecule that modifies MglA/SspA interaction and impairs intramacrophage survival of Francisella tularensisProfile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assaysThe potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffoldsSelectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase InhibitorsInvestigating Apoptozole as a Chemical Probe for HSP70 InhibitionInhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumorsChemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsEpigenetic assays for chemical biology and drug discovery.A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1The Essential Medicinal Chemistry of CurcuminTetrazine ligation for chemical proteomics.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.Composition and applications of focus libraries to phenotypic assaysCompound prioritization methods increase rates of chemical probe discovery in model organisms.Histone deacetylase inhibition increases levels of choline kinase α and phosphocholine facilitating noninvasive imaging in human cancers.Towards patient-based cancer therapeutics.The use of small molecule probes to study spatially separated stimulus-induced signaling pathways.Automatically detecting workflows in PubChem.Target validation using chemical probes.The promise and peril of chemical probes.Selective inhibitors of protein methyltransferasesPotent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).Mitigating risk in academic preclinical drug discovery.FAF-Drugs3: a web server for compound property calculation and chemical library design.Hsp90 molecular chaperone inhibitors: are we there yet?Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.Exquisitely specific bisubstrate inhibitors of c-Src kinase.KNIME Workflow to Assess PAINS Filters in SMARTS Format. Comparison of RDKit and Indigo Cheminformatics Libraries.
P2860
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P2860
Probing the probes: fitness factors for small molecule tools.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Probing the probes: fitness factors for small molecule tools.
@ast
Probing the probes: fitness factors for small molecule tools.
@en
Probing the probes: fitness factors for small molecule tools.
@nl
type
label
Probing the probes: fitness factors for small molecule tools.
@ast
Probing the probes: fitness factors for small molecule tools.
@en
Probing the probes: fitness factors for small molecule tools.
@nl
prefLabel
Probing the probes: fitness factors for small molecule tools.
@ast
Probing the probes: fitness factors for small molecule tools.
@en
Probing the probes: fitness factors for small molecule tools.
@nl
P2860
P1476
Probing the probes: fitness factors for small molecule tools.
@en
P2093
Ian Collins
P2860
P304
P356
10.1016/J.CHEMBIOL.2010.05.013
P50
P577
2010-06-01T00:00:00Z