Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.
about
Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groupsThree-dimensional compound comparison methods and their application in drug discoveryHit identification and optimization in virtual screening: practical recommendations based on a critical literature analysisRational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replicationCrystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding siteNew Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of ActionInterrogating HIV integrase for compounds that bind- a SAMPL challengeA New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core DomainA symmetric region of the HIV-1 integrase dimerization interface is essential for viral replicationNon-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cellsEvidence of conformational selection driving the formation of ligand binding sites in protein-protein interfacesUltra-High-Throughput Structure-Based Virtual Screening for Small-Molecule Inhibitors of Protein-Protein Interactions.Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitorHIV-1 IN inhibitors: 2010 update and perspectivesFrom laptop to benchtop to bedside: structure-based drug design on protein targets.Peptides that inhibit HIV-1 integrase by blocking its protein-protein interactions.Allosteric inhibitor development targeting HIV-1 integrase.Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging.Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.Novel integrase inhibitors for HIV.Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional InsightsPharmacophore-based virtual screening: a review of recent applications.LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014)."Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.Different Pathways Leading to Integrase Inhibitors ResistanceInhibiting the HIV integration process: past, present, and the future.Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues.Prospective strategies for targeting HIV-1 integrase function.Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors.Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor.Cellular cofactors of lentiviral integrase: from target validation to drug discovery.Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors.Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors.Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking.Computational close up on protein-protein interactions: how to unravel the invisible using molecular dynamics simulations?Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase
P2860
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P2860
Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Pharmacophore-based discovery ...... d cellular cofactor LEDGF/p75.
@ast
Pharmacophore-based discovery ...... d cellular cofactor LEDGF/p75.
@en
type
label
Pharmacophore-based discovery ...... d cellular cofactor LEDGF/p75.
@ast
Pharmacophore-based discovery ...... d cellular cofactor LEDGF/p75.
@en
prefLabel
Pharmacophore-based discovery ...... d cellular cofactor LEDGF/p75.
@ast
Pharmacophore-based discovery ...... d cellular cofactor LEDGF/p75.
@en
P2093
P2860
P50
P356
P1433
P1476
Pharmacophore-based discovery ...... d cellular cofactor LEDGF/p75.
@en
P2093
Anna Maria Monforte
Nunzio Iraci
Stefania Ferro
P2860
P304
P356
10.1002/CMDC.200900070
P577
2009-08-01T00:00:00Z