AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.

AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.

Item
http://www.wikidata.org/entity/Q33484430
A knock-in mouse model for the R120G mutation of αB-crystallin recapitulates human hereditary myopathy and cataracts.The common modification in alphaA-crystallin in the lens, N101D, is associated with increased opacity in a mouse model.Enhancement of ubiquitin conjugation activity reduces intracellular aggregation of V76D mutant γD-crystallin.p62 expression and autophagy in αB-crystallin R120G mutant knock-in mouse model of hereditary cataract.Engineering subtle targeted mutations into the mouse genome.Quantitative biometric phenotype analysis in mouse lenses.Patterns of gene expression in microarrays and expressed sequence tags from normal and cataractous lensesOligomerization with wt αA- and αB-crystallins reduces proteasome-mediated degradation of C-terminally truncated αA-crystallin.Activation of the unfolded protein response by a cataract-associated αA-crystallin mutation.
P2860

AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.

Item
http://www.wikidata.org/entity/Q33484430
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
AlphaA-crystallin R49Cneo muta ...... and nuclear cataracts in mice.
@ast
AlphaA-crystallin R49Cneo muta ...... and nuclear cataracts in mice.
@en
type
label
AlphaA-crystallin R49Cneo muta ...... and nuclear cataracts in mice.
@ast
AlphaA-crystallin R49Cneo muta ...... and nuclear cataracts in mice.
@en
prefLabel
AlphaA-crystallin R49Cneo muta ...... and nuclear cataracts in mice.
@ast
AlphaA-crystallin R49Cneo muta ...... and nuclear cataracts in mice.
@en
P1433
P1476
P2860
P2888
P304
P31
P356
P478
P50
P577
P5875
P6179
P698
P932
P356
P1433
P1476
AlphaA-crystallin R49Cneo muta ...... and nuclear cataracts in mice.
@en
P2860
P2888
P304
P31
P356
P478
P50
P577
P5875
P6179
P698
P932