The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress
about
Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21qActivation of metallothioneins and alpha-crystallin/sHSPs in human lens epithelial cells by specific metals and the metal content of aging clear human lensesMorphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lensThe Photobiology of Lutein and Zeaxanthin in the EyeMechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell deathChanges in protein profiles of guinea pig sclera during development of form deprivation myopia and recoveryThe R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis.AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.Detection and prevention of ocular phototoxicity of ciprofloxacin and other fluoroquinolone antibioticsThe role of a lens survival pathway including sox2 and αA-crystallin in the evolution of cavefish eye degeneration.αA-Crystallin associates with α6 integrin receptor complexes and regulates cellular signaling.Molecular mechanism of formation of cortical opacity in CRYAAN101D transgenic mice.Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosisActin cytoskeleton and small heat shock proteins: how do they interact?Inhibition of lens photodamage by UV-absorbing contact lenses.A conserved role of αA-crystallin in the development of the zebrafish embryonic lens.Novel roles for α-crystallins in retinal function and disease.Phototoxicity and cytotoxicity of fullerol in human lens epithelial cellsThe lens epithelium: focus on the expression and function of the alpha-crystallin chaperones.Importance of eye lens α-crystallin heteropolymer with 3:1 αA to αB ratio: stability, aggregation, and modifications.Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells.Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins αA- and αB-crystallin.Mechanism of insolubilization by a single-point mutation in alphaA-crystallin linked with hereditary human cataracts.COOH-terminal truncations and site-directed mutations enhance thermostability and chaperone-like activity of porcine alphaB-crystallin.Cloning of crystallin from orange-spotted grouper and characterization of its activity as potential protective agent.Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells.In vivo lens deficiency of the R49C alphaA-crystallin mutant.Differential protective activity of alpha A- and alphaB-crystallin in lens epithelial cells.Quantitative biometric phenotype analysis in mouse lenses.Activation of the unfolded protein response by a cataract-associated αA-crystallin mutation.Reduction of experimental diabetic vascular leakage and pericyte apoptosis in mice by delivery of αA-crystallin with a recombinant adenovirus.ATP causes small heat shock proteins to release denatured protein.Suppression of DTT-induced aggregation of abrin by alphaA- and alphaB-crystallins: a model aggregation assay for alpha-crystallin chaperone activity in vitro.Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.
P2860
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P2860
The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress
description
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1998
@ast
im November 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/11/20)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/11/20)
@nl
наукова стаття, опублікована в листопаді 1998
@uk
name
The molecular chaperone alphaA ...... h and resistance to UVA stress
@ast
The molecular chaperone alphaA ...... h and resistance to UVA stress
@en
The molecular chaperone alphaA ...... h and resistance to UVA stress
@nl
type
label
The molecular chaperone alphaA ...... h and resistance to UVA stress
@ast
The molecular chaperone alphaA ...... h and resistance to UVA stress
@en
The molecular chaperone alphaA ...... h and resistance to UVA stress
@nl
prefLabel
The molecular chaperone alphaA ...... h and resistance to UVA stress
@ast
The molecular chaperone alphaA ...... h and resistance to UVA stress
@en
The molecular chaperone alphaA ...... h and resistance to UVA stress
@nl
P2860
P356
P1476
The molecular chaperone alphaA ...... h and resistance to UVA stress
@en
P2093
P2860
P304
31252-31261
P356
10.1074/JBC.273.47.31252
P407
P577
1998-11-01T00:00:00Z