In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids
about
Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteriaLanthipeptides: chemical synthesis versus in vivo biosynthesis as tools for pharmaceutical productionBioengineering Lantibiotics for Therapeutic SuccessType AII lantibiotic bovicin HJ50 with a rare disulfide bond: structure, structure-activity relationships and mode of actionSynthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via CuAAC-/hydrazide-mediated cyclizationProduction of lantipeptides in Escherichia coli.Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamidesArtificial lantipeptides from in vitro translations.Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcMSynthesis of trypsin-resistant variants of the Listeria-active bacteriocin salivaricin PGeneration of an actagardine A variant library through saturation mutagenesis.Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2.Photochemical cleavage of leader peptides.Bovicin HJ50-like lantibiotics, a novel subgroup of lantibiotics featured by an indispensable disulfide bridge.Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactateCombinatorial biosynthesis of RiPPs: docking with marine life.Chemical synthesis and biological activity of analogues of the lantibiotic epilancin 15X.An engineered lantibiotic synthetase that does not require a leader peptide on its substrate.Non-proteinogenic amino acids in lacticin 481 analogues result in more potent inhibition of peptidoglycan transglycosylation.Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis.Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry.A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization.Follow the leader: the use of leader peptides to guide natural product biosynthesis.Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis.One-pot synthesis of class II lanthipeptide bovicin HJ50 via an engineered lanthipeptide synthetase.Restoration of bioactive lantibiotic suicin from a remnant lan locus of pathogenic Streptococcus suis serotype 2.Fundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides.The dawning of a 'Golden era' in lantibiotic bioengineering.The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides.Discovery and development of lantibiotics; antimicrobial agents that have significant potential for medical application.Increasing the success rate of lantibiotic drug discovery by Synthetic Biology.Advances in the arsenal of tools available enabling the discovery of novel lantibiotics with therapeutic potential.Multipronged approach for engineering novel peptide analogues of existing lantibiotics.Anaerobes as Sources of Bioactive Compounds and Health Promoting Tools.Employing the promiscuity of lantibiotic biosynthetic machineries to produce novel antimicrobials.Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.Incorporation of tryptophan analogues into the lantibiotic nisin.Bioinspired strategy for the ribosomal synthesis of thioether-bridged macrocyclic peptides in bacteria.Synthesis of the AviMeCys-containing D-ring of mersacidin.
P2860
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P2860
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids
@ast
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids
@en
type
label
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids
@ast
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids
@en
prefLabel
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids
@ast
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids
@en
P2093
P2860
P356
P1476
In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids
@en
P2093
Matthew R Levengood
Patrick J Knerr
Trent J Oman
P2860
P304
12024-12025
P356
10.1021/JA903239S
P407
P577
2009-09-01T00:00:00Z