A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis. - Wikidata - awgldk - TriplyDB

A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis.

A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis.

http://www.wikidata.org/entity/Q33493409

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Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase Genome-wide matching of genes to cellular roles using guilt-by-association models derived from single sample analysis LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2 The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression The emerging paradigm of network medicine in the study of human disease Loss of the nuclear receptor corepressor SLIRP compromises male fertility TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome LRPPRC mutation suppresses cytochrome oxidase activity by altering mitochondrial RNA transcript stability in a mouse model Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria.Mitochondrial and nuclear genomic responses to loss of LRPPRC expression.A compendium of human mitochondrial gene expression machinery with links to disease.Targeting of the cytosolic poly(A) binding protein PABPC1 to mitochondria causes mitochondrial translation inhibition Knockdown of the cellular protein LRPPRC attenuates HIV-1 infection.Association of genes with physiological functions by comparative analysis of pooled expression microarray data.Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect.Discovery of cellular proteins required for the early steps of HCV infection using integrative genomics.Tissue-specific responses to the LRPPRC founder mutation in French Canadian Leigh Syndrome Functional genomic analysis of human mitochondrial RNA processing.Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.The mitochondrial proteome and human disease.CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation.Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function.SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation.Transcriptome analysis of complex I-deficient patients reveals distinct expression programs for subunits and assembly factors of the oxidative phosphorylation system.Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response Mitochondrial transcript maturation and its disorders LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.WeGET: predicting new genes for molecular systems by weighted co-expression.Mutation in the novel nuclear-encoded mitochondrial protein CHCHD10 in a family with autosomal dominant mitochondrial myopathy.Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein.Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain.Mitochondrial CHCHD-Containing Proteins: Physiologic Functions and Link with Neurodegenerative Diseases.Global subcellular characterization of protein degradation using quantitative proteomics.

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P2860

A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis.

http://www.wikidata.org/entity/Q33493409

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

A computational screen for reg ...... mitochondrial RNA homeostasis.

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A computational screen for reg ...... mitochondrial RNA homeostasis.

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type

label

A computational screen for reg ...... mitochondrial RNA homeostasis.

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A computational screen for reg ...... mitochondrial RNA homeostasis.

@en

prefLabel

A computational screen for reg ...... mitochondrial RNA homeostasis.

@ast

A computational screen for reg ...... mitochondrial RNA homeostasis.

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A computational screen for reg ...... mitochondrial RNA homeostasis.

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Daniel H Arlow

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Joshua M Baughman

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Vamsi K Mootha

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Vishal M Gohil

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Zareen Gauhar

http://www.w3.org/2001/XMLSchema#string

P2860

Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells

Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1)

Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria

hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly

The role of the LRPPRC (leucine-rich pentatricopeptide repeat cassette) gene in cytochrome oxidase assembly: mutation causes lowered levels of COX (cytochrome c oxidase) I and COX III mRNA

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data.

Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics.

Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis

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19680543

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phosphorylation

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