Two alleles of a neural protein gene linked to scrapie in sheep.
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The Cellular Prion Protein: A Player in Immunological QuiescenceGenetics of Prion Disease in CattlePrion shedding from olfactory neurons into nasal secretionsSheep prion protein synthetic peptide spanning helix 1 and beta-strand 2 (residues 142-166) shows beta-hairpin structure in solutionInsight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variantsCritical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion proteincDNA cloning of a novel heterogeneous nuclear ribonucleoprotein gene homologue in Caenorhabditis elegans using hamster prion protein cDNA as a hybridization probeMolecular cloning of a candidate chicken prion protein.PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattleAnalysis of multiple single nucleotide polymorphisms closely positioned in the ovine PRNP gene using linear fluorescent probes and melting curve analysis.Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo.Frequent missense and insertion/deletion polymorphisms in the ovine Shadoo gene parallel species-specific variation in PrP.Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp.Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171.Nanopore analysis reveals differences in structural stability of ovine PrP(C) proteins corresponding to scrapie susceptible (VRQ) and resistance (ARR) genotypes.Influence of the prion protein gene, Prnp, on scrapie susceptibility in sheep.Microsecond unfolding kinetics of sheep prion protein reveals an intermediate that correlates with susceptibility to classical scrapie.Spontaneous conversion of PrPC to PrPSc.Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein.Resistance to scrapie in PrP ARR/ARQ heterozygous sheep is not caused by preferential allelic useCharacterization of prion protein (PrP)-derived peptides that discriminate full-length PrPSc from PrPC.Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goatsPurification and properties of the cellular prion protein from Syrian hamster brain.Prion Type-Dependent Deposition of PRNP Allelic Products in Heterozygous Sheep.Molecular biology and pathology of scrapie and the prion diseases of humans.Possible role of region 152-156 in the structural duality of a peptide fragment from sheep prion protein.Molecular biology and transgenetics of prion diseases.A critical analysis of disease-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig.Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.Identification of new quantitative trait Loci (other than the PRNP gene) modulating the scrapie incubation period in sheep.Molecular location of a species-specific epitope on the hamster scrapie agent protein.Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms.Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3.Structural factors underlying the species barrier and susceptibility to infection in prion disease.Prion protein self-interaction in prion disease therapy approaches.Expanding possibilities for intervention against small ruminant lentiviruses through genetic marker-assisted selective breeding.The transmissible spongiform encephalopathies of livestock.Allelic frequency and genotypes of prion protein at codon 136 and 171 in Iranian Ghezel sheep breeds.Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP.Efficient transmission of two different sheep scrapie isolates in transgenic mice expressing the ovine PrP gene.
P2860
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P2860
Two alleles of a neural protein gene linked to scrapie in sheep.
description
1990 nî lūn-bûn
@nan
1990 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Two alleles of a neural protein gene linked to scrapie in sheep.
@ast
Two alleles of a neural protein gene linked to scrapie in sheep.
@en
type
label
Two alleles of a neural protein gene linked to scrapie in sheep.
@ast
Two alleles of a neural protein gene linked to scrapie in sheep.
@en
prefLabel
Two alleles of a neural protein gene linked to scrapie in sheep.
@ast
Two alleles of a neural protein gene linked to scrapie in sheep.
@en
P2093
P2860
P356
P1476
Two alleles of a neural protein gene linked to scrapie in sheep.
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.7.2476
P407
P577
1990-04-01T00:00:00Z