Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
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Glypican-1 mediates both prion protein lipid raft association and disease isoform formationLysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulationCellular aspects of prion replication in vitroPrion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic targetCalcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survivalStructure of the Flexible Amino-Terminal Domain of Prion Protein Bound to a Sulfated GlycanA computational approach for identifying the chemical factors involved in the glycosaminoglycans-mediated acceleration of amyloid fibril formationAnti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cellsAcquisition of drug resistance and dependence by prionsStructure-Based Drug Discovery for Prion Disease Using a Novel Binding SimulationCharge neutralization of the central lysine cluster in prion protein (PrP) promotes PrP(Sc)-like folding of recombinant PrP amyloids.Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy.Identification of a gene regulatory network associated with prion replication.Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversionTetracyclines affect prion infectivity.Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and websNew inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products.Direct detection of soil-bound prions.Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoringHeparin binding confers prion stability and impairs its aggregation.Sulfated dextrans enhance in vitro amplification of bovine spongiform encephalopathy PrP(Sc) and enable ultrasensitive detection of bovine PrP(Sc).Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures.Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent.Deletion of beta-strand and alpha-helix secondary structure in normal prion protein inhibits formation of its protease-resistant isoform.Coinfecting prion strains compete for a limiting cellular resource.Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody.Acridine and phenothiazine derivatives as pharmacotherapeutics for prion diseaseDiphenylpyrazole-derived compounds increase survival time of mice after prion infection.Cell-based quantification of chronic wasting disease prions.Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cellsScrapie strains maintain biological phenotypes on propagation in a cell line in culture.Heparan sulfate biosynthesis: a theoretical study of the initial sulfation step by N-deacetylase/N-sulfotransferaseInhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting diseaseMefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivoSpecies specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrierComparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cellsTransfer of a prion strain to different hosts leads to emergence of strain variants.Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides.A bovine cell line that can be infected by natural sheep scrapie prions.
P2860
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P2860
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
@ast
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
@en
type
label
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
@ast
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
@en
prefLabel
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
@ast
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
@en
P2860
P1433
P1476
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
@en
P2093
G J Raymond
P2860
P304
P407
P577
1993-02-01T00:00:00Z