Controlled in situ preparation of A beta(1-42) oligomers from the isopeptide "iso-A beta(1-42)", physicochemical and biological characterization.
about
A foldamer-dendrimer conjugate neutralizes synaptotoxic β-amyloid oligomersSimultaneous changes of spatial memory and spine density after intrahippocampal administration of fibrillar aβ1-42 to the rat brainInteractions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synucleinAbeta(1-42) enhances neuronal excitability in the CA1 via NR2B subunit-containing NMDA receptorsOverexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice.Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory.In vitro and in vivo characterization of several functionalized ultrasmall particles of iron oxide, vectorized against amyloid plaques and potentially able to cross the blood-brain barrier: toward earlier diagnosis of Alzheimer's disease by moleculaLight-controlled toxicity of engineered amyloid β-peptides.Proteomic study of the toxic effect of oligomeric Aβ1-42 in situ prepared from 'iso-Aβ1-42'.Acute intracerebral treatment with amyloid-beta (1-42) alters the profile of neuronal oscillations that accompany LTP induction and results in impaired LTP in freely behaving rats.Click Peptide concept: o-acyl isopeptide of islet amyloid polypeptide as a nonaggregative precursor molecule.Synthesis of O-acyl isopeptides.Studies for Improving a Rat Model of Alzheimer's Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory.Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome.Exceptional in vivo catabolism of neurodegeneration-related aggregates.O-acyl isopeptide method: development of an O-acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1-42 isopeptide.Opposite effect of Ca2+/Mg2+ ions on the aggregation of native and precursor-derived Aβ42
P2860
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P2860
Controlled in situ preparation of A beta(1-42) oligomers from the isopeptide "iso-A beta(1-42)", physicochemical and biological characterization.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Controlled in situ preparation ...... d biological characterization.
@ast
Controlled in situ preparation ...... d biological characterization.
@en
Controlled in situ preparation ...... d biological characterization.
@nl
type
label
Controlled in situ preparation ...... d biological characterization.
@ast
Controlled in situ preparation ...... d biological characterization.
@en
Controlled in situ preparation ...... d biological characterization.
@nl
prefLabel
Controlled in situ preparation ...... d biological characterization.
@ast
Controlled in situ preparation ...... d biological characterization.
@en
Controlled in situ preparation ...... d biological characterization.
@nl
P2093
P1433
P1476
Controlled in situ preparation ...... d biological characterization.
@en
P2093
Agnes Kasza
Anasztázia Hetényi
Botond Penke
Dóra Simon
Edit Wéber
Hajnalka Tóháti
Ilona Laczkó
Katalin Soós
Lívia Fülöp
Mária Csete
P304
P356
10.1016/J.PEPTIDES.2009.12.001
P577
2009-12-06T00:00:00Z