Sulfated, low-molecular-weight lignins are potent inhibitorsof plasmin, in addition to thrombin and factor Xa: Novel opportunity for controlling complex pathologies.
about
Rational design of potent, small, synthetic allosteric inhibitors of thrombinDevelopment of Orally Active Thrombin Inhibitors for the Treatment of Thrombotic Disorder DiseasesInteraction of Thrombin with Sucrose OctasulfateTargeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effectsNew parenteral anticoagulants in development.Lignins and Their Derivatives with Beneficial Effects on Human Health.Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides.Sulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin.Polysulfated trehalose as a novel anticoagulant agent with dual mode of action.Identification of the site of binding of sulfated, low molecular weight lignins on thrombinPlasmin regulation through allosteric, sulfated, small molecules.Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases.Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin.Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.Emerging sulfated flavonoids and other polyphenols as drugs: nature as an inspiration.Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders.Structure-activity relationship studies for multitarget antithrombotic drugs.
P2860
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P2860
Sulfated, low-molecular-weight lignins are potent inhibitorsof plasmin, in addition to thrombin and factor Xa: Novel opportunity for controlling complex pathologies.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@ast
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@en
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@nl
type
label
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@ast
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@en
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@nl
prefLabel
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@ast
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@en
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@nl
P2093
P2860
P356
P1476
Sulfated, low-molecular-weight ...... ntrolling complex pathologies.
@en
P2093
Brian L Henry
May Abdel Aziz
Qibing Zhou
Umesh R Desai
P2860
P304
P356
10.1160/TH09-07-0454
P577
2009-12-18T00:00:00Z