A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids
about
Rational design of potent, small, synthetic allosteric inhibitors of thrombinInteraction of Thrombin with Sucrose OctasulfateTargeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effectsAn update on recent patents on thrombin inhibitors (2010 - 2013)Designing Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Subsites That Can Be Targeted by Sulfated Small Molecules for Inducing InhibitionNew parenteral anticoagulants in development.Interaction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function.First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor XaSulfated, low-molecular-weight lignins are potent inhibitorsof plasmin, in addition to thrombin and factor Xa: Novel opportunity for controlling complex pathologies.Lignins and Their Derivatives with Beneficial Effects on Human Health.Characterization of the plasma and blood anticoagulant potential of structurally and mechanistically novel oligomers of 4-hydroxycinnamic acidsDynamic affinity chromatography in the separation of sulfated lignins binding to thrombin.Nonsulfated, cinnamic acid-based lignins are potent antagonists of HSV-1 entry into cells.Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site.Sulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin.Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitorsIdentification of the site of binding of sulfated, low molecular weight lignins on thrombinSulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases.Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin.Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.Scintillation proximity assay for measurement of RNA methylation.Developments in factor Xa inhibitors for the treatment of thromboembolic disorders.Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders.Highly efficient control of thrombin activity by multivalent nanoparticles.Synthesis and evaluation of a series of 3,4,5-trimethoxycinnamic acid derivatives as potential antinarcotic agents.Novel low molecular weight lignins as potential anti-emphysema agents: In vitro triple inhibitory activity against elastase, oxidation and inflammation.Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptorsStructural glycobiology of heparin dynamics on the exosite 2 of coagulation cascade proteases: Implications for glycosaminoglycans antithrombotic activity.Sulfated caffeic acid dehydropolymer attenuates elastase and cigarette smoke extract-induced emphysema in rats: sustained activity and a need of pulmonary delivery.Phenolic fractions from nine Trifolium species modulate the coagulant properties of blood plasma in vitro without cytotoxicity towards blood cells.A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin.Spirulan from blue-green algae inhibits fibrin and blood clots: its potent antithrombotic effects.Comparative Effect of Quercetin and Quercetin-3-O-β-d-Glucoside on Fibrin Polymers, Blood Clots, and in Rodent Models.Antithrombotic Activities of Luteolin In Vitro and In Vivo.
P2860
Q24623182-43A507C0-937A-4C9B-A4F1-9BA8A0265BFAQ27670722-63A34165-7371-4469-8404-405597FB6408Q28236023-1836CD89-1304-4A1B-A897-095E55B00EF8Q28299898-8E95F7E1-0DA8-4E9A-A18A-071EF68CEA9CQ29040782-49F40C10-F237-4254-8C93-89826211158EQ33392647-A115146B-F57D-4BB0-8E32-53F9EBCDA119Q33460885-8D9610D1-699D-4995-B17E-E80668096563Q33470885-4B881671-98BE-46FB-82D0-8CAC4C0087BCQ33519982-0A7459A6-8623-465F-B7D6-3D1538BD3A15Q33838761-FC2DE810-0A38-4170-B9B6-12E660DD293EQ33899404-521AF0BB-F263-454D-95F0-61AB968CA0D4Q33905734-F98D70B4-DE3D-45ED-8A6E-F496314E3790Q33941609-FE77511E-2DBF-4644-8C5C-DD6E925163FFQ34264585-9CC55AF3-9653-4494-9490-AC16C5FF2F59Q34604052-67700D7D-725C-4BDB-8703-6C609B742A71Q34620681-7FF41F22-A875-4EAB-8B71-B3AEEC995F38Q35049040-659031C6-20FC-4942-8199-CCB5A9F0D7A1Q35242133-33460804-0AC9-48E6-BE36-64631A818CD3Q35675434-C72580DA-9D68-4378-9FCB-CB7B2CFFB8BCQ35981965-C51E0405-7807-433F-98DE-E6F3D8FB068EQ36129629-DE096A37-70D2-4314-8AF5-74A7D04D16D5Q36157083-F0D2230D-5F2E-45C6-A21A-5A4379EEB104Q36788507-D251C3AD-99FF-4831-9E62-F19D1360BB6DQ37118771-637A6527-527A-43F8-BF81-AA0599DDEA93Q37646551-611146B6-8CDA-4132-91E6-2502A47B446CQ38198582-CBD75304-0D98-4C40-B2E8-C54D78039795Q38332550-40A72E6C-9186-4DEA-9124-546D081BD4DDQ38456816-5FCCD1CC-638D-41A7-BE3E-3EA15EBB48DEQ41898941-0D74E138-E0A9-4D92-BBFC-A7318CB70D6BQ42054506-54A11380-9ED5-49CC-AC25-08D5D3B9C2B6Q44505808-69A8E77E-8713-4EB0-ACFF-51000566D886Q44998183-EC78110E-2FDD-481B-A52F-779A341C91E9Q48229543-23ABE02A-D290-41A5-B57E-543C4484808EQ49833933-FD2DD8A0-BDEA-459D-94BA-74058EDE0C65Q50217810-3493C4C0-41A5-4AF1-BDE9-F5D9623E1EACQ51715646-F5EF3CAF-257F-47BF-B760-E930C56CCEB1Q53421955-6D64A313-5250-44E2-B47D-AA468E280A3A
P2860
A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@ast
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@en
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@nl
type
label
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@ast
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@en
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@nl
prefLabel
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@ast
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@en
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@nl
P2860
P3181
P356
P1476
A novel allosteric pathway of ...... ers of 4-hydroxycinnamic acids
@en
P2093
Bernhard H Monien
Brian L Henry
P2860
P304
31891-31899
P3181
P356
10.1074/JBC.M704257200
P407
P577
2007-09-05T00:00:00Z