Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. - Wikidata - awgldk - TriplyDB

Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.

Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.

http://www.wikidata.org/entity/Q33522347

about

Chk1 suppressed cell death Genomic instability in liver cells caused by an LPS-induced bystander-like effect Persistent DNA damage after high dose in vivo gamma exposure of minipig skin.The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX.A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089.H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues.PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels.Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.Rad51 in regulating the radiosensitivity of non-small cell lung cancer with different epidermal growth factor receptor mutation status.Characterization of the role of Fhit in suppression of DNA damage.Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry.Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.Replication stress and cancer: it takes two to tango.Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.Evaluation of surrogate tissues as indicators of drug activity in a melanoma skin model Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions.An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation.HUWE1 interacts with PCNA to alleviate replication stress.Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.DNA Repair in Despair-Vitamin D Is Not Fair.Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons.CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress.Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors.E1a promotes c-Myc-dependent replicative stress: implications in glioblastoma radiosensitization.Dual effect of heat shock on DNA replication and genome integrity.Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress.Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress.Development of pharmacodynamic biomarkers for ATR inhibitors.

P2860

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P2860

Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.

http://www.wikidata.org/entity/Q33522347

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@ast

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@en

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@nl

type

label

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@ast

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@en

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@nl

prefLabel

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@ast

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@en

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@nl

P1433

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P2860

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P356

MBC.E09-07-0618

P1433

Molecular Biology of the Cell

P1476

Enhanced H2AX phosphorylation, ...... death in the absence of Chk1.

@en

P2093

Mark Meuth

http://www.w3.org/2001/XMLSchema#string

Mary E Gagou

http://www.w3.org/2001/XMLSchema#string

Pedro Zuazua-Villar

http://www.w3.org/2001/XMLSchema#string

P2860

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

Megabase chromatin domains involved in DNA double-strand breaks in vivo

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

WAF1, a potential mediator of p53 tumor suppression

P304

739-752

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scholarly article

P356

10.1091/MBC.E09-07-0618

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5

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P478

21

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2010-01-06T00:00:00Z

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20053681

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phosphorylation

P932

2828961

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