Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments.
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First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosisDiscovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moietyA cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylationReducing agents affect inhibitory activities of compounds: results from multiple drug targets.Apparent activity in high-throughput screening: origins of compound-dependent assay interferenceIdentifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review.High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4.Cysteine 81 is critical for the interaction of S100A4 and myosin-IIAIdentification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidaseThe essential roles of chemistry in high-throughput screening triagePAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitorsIntegrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery.Metal impurities cause false positives in high-throughput screening campaignsPost-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.Non-stoichiometric inhibition in integrated lead finding - a literature review.Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small MoleculesAminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation.Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?A Computational Investigation of Small-Molecule Engagement of Hot Spots at Protein-Protein Interaction Interfaces.Switching Futile para-Quinone to Efficient Reactive Oxygen Species Generator: Ubiquitin-Specific Protease-2 Inhibition, Electrocatalysis, and Quantification.Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.The importance of triaging in determining the quality of output from high-throughput screening.A sensitive luminescent assay for the histone methyltransferase NSD1 and other SAM-dependent enzymes.Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2.A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development.Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.Mimicking Intermolecular Interactions of Tight Protein-Protein Complexes for Small-Molecule Antagonists.Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells.New Approaches to Difficult Drug Targets: The Phosphatase StoryChemical motifs that redox cycle and their associated toxicityHigh-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2
P2860
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P2860
Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Profiling the NIH Small Molecu ...... ling in reducing environments.
@ast
Profiling the NIH Small Molecu ...... ling in reducing environments.
@en
Profiling the NIH Small Molecu ...... ling in reducing environments.
@nl
type
label
Profiling the NIH Small Molecu ...... ling in reducing environments.
@ast
Profiling the NIH Small Molecu ...... ling in reducing environments.
@en
Profiling the NIH Small Molecu ...... ling in reducing environments.
@nl
prefLabel
Profiling the NIH Small Molecu ...... ling in reducing environments.
@ast
Profiling the NIH Small Molecu ...... ling in reducing environments.
@en
Profiling the NIH Small Molecu ...... ling in reducing environments.
@nl
P2093
P2860
P50
P356
P1476
Profiling the NIH Small Molecu ...... ling in reducing environments.
@en
P2093
Harold K Takyi
Karina M Soares
Nicole Blackmon
Sunita N Shinde
P2860
P304
P356
10.1089/ADT.2009.0247
P577
2010-04-01T00:00:00Z