Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).
about
P1343
Insights into granulosa cell tumors using spontaneous or genetically engineered mouse modelsThe FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary.The disparate origins of ovarian cancers: pathogenesis and prevention strategies.FOXL2 suppresses proliferation, invasion and promotes apoptosis of cervical cancer cellsBetaglycan alters NFκB-TGFβ2 cross talk to reduce survival of human granulosa tumor cells.Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoterHER2 and GATA4 are new prognostic factors for early-stage ovarian granulosa cell tumor-a long-term follow-up study.LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity.Refined mapping of a quantitative trait locus on chromosome 1 responsible for mouse embryonic death.The transcriptional targets of mutant FOXL2 in granulosa cell tumours.A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors.Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads.Overexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors.Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathologyCombined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes.17β-estradiol inhibits spreading of metastatic cells from granulosa cell tumors through a non-genomic mechanism involving GPER1Fine map of the Gct1 spontaneous ovarian granulosa cell tumor locus.Essential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434.Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cellsFOXL2 molecular status in adult granulosa cell tumors of the ovary: A study of primary and metastatic casesIdentification of the forkhead transcriptional factor 2 (FOXL2) gene mutations in four Chinese families with blepharophimosis syndrome.Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature.Characterization of the inhibitor of kappaB kinase (IKK) complex in granulosa cell tumors of the ovary and granulosa cell tumor-derived cell lines.Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation.Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase.Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134W).Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary.Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†.Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary.The molecular mechanism of ovarian granulosa cell tumors.FOXL2 posttranslational modifications mediated by GSK3β determine the growth of granulosa cell tumours.Nuclear Receptor Profiling of Ovarian Granulosa Cell Tumors
P2860
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P2860
Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Functional exploration of the ...... tation p.Cys134Trp (c.402C>G).
@ast
Functional exploration of the ...... tation p.Cys134Trp (c.402C>G).
@en
Functional exploration of the ...... tic FOXL2 mutation p.Cys134Trp
@nl
type
label
Functional exploration of the ...... tation p.Cys134Trp (c.402C>G).
@ast
Functional exploration of the ...... tation p.Cys134Trp (c.402C>G).
@en
Functional exploration of the ...... tic FOXL2 mutation p.Cys134Trp
@nl
prefLabel
Functional exploration of the ...... tation p.Cys134Trp (c.402C>G).
@ast
Functional exploration of the ...... tation p.Cys134Trp (c.402C>G).
@en
Functional exploration of the ...... tic FOXL2 mutation p.Cys134Trp
@nl
P2093
P2860
P50
P1433
P1476
Functional exploration of the ...... utation p.Cys134Trp (c.402C>G)
@en
P2093
Anne-Laure Todeschini
Aurélie Dipietromaria
Barbara D'Haene
David L'Hôte
Marc Fellous
Reiner A Veitia
P2860
P356
10.1371/JOURNAL.PONE.0008789
P407
P4510
P50
P577
2010-01-20T00:00:00Z