FoxL2 and Smad3 coordinately regulate follistatin gene transcription - Wikidata - awgldk - TriplyDB

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

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Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.The follistatin-288 isoform alone is sufficient for survival but not for normal fertility in mice Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells.Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice Impaired FSHbeta expression in the pituitaries of Foxl2 mutant animals.Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).FOXL2 suppresses proliferation, invasion and promotes apoptosis of cervical cancer cells Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?Pituitary gland development and disease: from stem cell to hormone production Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes.Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene.Novel action of FOXL2 as mediator of Col1a2 gene autoregulation.LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity.Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.A FoxL in the Smad house: activin regulation of FSH.Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.Disorders of sex development: new genes, new concepts.FOXL2 in human endometrium: hyperexpressed in endometriosis.The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells.Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes Identification of miRNAs associated with sexual maturity in chicken ovary by Illumina small RNA deep sequencing The Local Control of the Pituitary by Activin Signaling and Modulation.Mutant Forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation.Molecular mechanisms of enhancing porcine granulosa cell proliferation and function by treatment in vitro with anti-inhibin alpha subunit antibody.Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathology FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development.Activins and Follistatin in Chronic Hepatitis C and Its Treatment with Pegylated-Interferon-α Based Therapy.Maximal expression of Foxl2 in pituitary gonadotropes requires ovarian hormones.FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter BRCA1 regulates follistatin function in ovarian cancer and human ovarian surface epithelial cells.Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin.Follistatin antagonizes activin signaling and acts with notum to direct planarian head regeneration.Essential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434.Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription The new molecular biology of granulosa cell tumors of the ovary.The forkhead transcription factor FOXL2 is expressed in somatic cells of the human ovary prior to follicle formation.Clinical and Therapeutic Implications of Follistatin in Solid Tumours.

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P2860

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

http://www.wikidata.org/entity/Q24655444

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

@ast

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

@en

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

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type

label

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

@ast

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

@en

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

@nl

prefLabel

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

@ast

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

@en

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

@nl

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P1433

Journal of Biological Chemistry

P1476

FoxL2 and Smad3 coordinately regulate follistatin gene transcription

@en

P2093

Amy L Blount

http://www.w3.org/2001/XMLSchema#string

Karsten Schmidt

http://www.w3.org/2001/XMLSchema#string

Louise M Bilezikjian

http://www.w3.org/2001/XMLSchema#string

Nicholas J Justice

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Wolfgang H Fischer

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Wylie W Vale

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P2860

The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome

Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function

Structural basis for the inhibition of activin signalling by follistatin.

Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

Evolution and expression of FOXL2

The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding

FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development

RNA secondary structure prediction by centroids in a Boltzmann weighted ensemble

Sfold web server for statistical folding and rational design of nucleic acids

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scholarly article

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10.1074/JBC.M806676200

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12

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284

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19106105

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P932

2658057

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