Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease
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Mechanisms of Hsp90 regulationProtein homeostasis as a therapeutic target for diseases of protein conformationTherapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseHuntington's disease: underlying molecular mechanisms and emerging conceptsHeat shock transcription factor 1 as a therapeutic target in neurodegenerative diseasesIdentification of a tissue-selective heat shock response regulatory networkUncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its ActivationHSF1 protects neurons through a novel trimerization- and HSP-independent mechanismThe chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosolInduction of heat shock proteins by hyperthermia and noise overstimulation in hsf1 -/- miceAltered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesDeciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.Getting folded: chaperone proteins in muscle development, maintenance and disease.Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndromeThe aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila.Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Therapeutic approaches to preventing cell death in Huntington diseaseThe biology of proteostasis in aging and disease.Regulation of the mammalian heat shock factor 1.Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation.Small-molecule proteostasis regulators for protein conformational diseases.Molecular chaperones in Parkinson's disease--present and futureA direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.The response to heat shock and oxidative stress in Saccharomyces cerevisiaeHeat shock response and insulin-associated neurodegeneration.High-throughput screening system for inhibitors of human Heat Shock Factor 2.Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.The Chemical Biology of Molecular Chaperones--Implications for Modulation of ProteostasisHeat shock factors: integrators of cell stress, development and lifespan.The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds.Rapid profiling of disease alleles using a tunable reporter of protein misfolding.Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle.
P2860
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P2860
Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Modulation of heat shock trans ...... n in neurodegenerative disease
@ast
Modulation of heat shock trans ...... n in neurodegenerative disease
@en
Modulation of heat shock trans ...... in neurodegenerative disease.
@nl
type
label
Modulation of heat shock trans ...... n in neurodegenerative disease
@ast
Modulation of heat shock trans ...... n in neurodegenerative disease
@en
Modulation of heat shock trans ...... in neurodegenerative disease.
@nl
prefLabel
Modulation of heat shock trans ...... n in neurodegenerative disease
@ast
Modulation of heat shock trans ...... n in neurodegenerative disease
@en
Modulation of heat shock trans ...... in neurodegenerative disease.
@nl
P2860
P1433
P1476
Modulation of heat shock trans ...... n in neurodegenerative disease
@en
P2093
Dennis J Thiele
Michelle L Turski
P2860
P304
P356
10.1371/JOURNAL.PBIO.1000291
P407
P577
2010-01-19T00:00:00Z