CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases. - Wikidata - awgldk - TriplyDB

CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.

CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.

http://www.wikidata.org/entity/Q33528991

about

Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis An intronic microRNA links Rb/E2F and EGFR signaling Dysregulation of ubiquitin ligases in cancer SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex A novel classification of lung cancer into molecular subtypes Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.Drug repositioning discovery for early- and late-stage non-small-cell lung cancer.As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia.Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human pancreatic cancer and is targeted by epidermal growth factor receptor inhibition.Molecularly targeted therapies in non-small-cell lung cancer annual update 2014 The role of the c-Met pathway in lung cancer and the potential for targeted therapy.Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation An E3 ubiquitin ligase: c-Cbl: a new therapeutic target of lung cancer.Deleterious c-Cbl Exon Skipping Contributes to Human Glioma.H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.MET as a possible target for non-small-cell lung cancer.High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis The lysosome as a command-and-control center for cellular metabolism.Cbl-b enhances sensitivity to 5-fluorouracil via EGFR- and mitochondria-mediated pathways in gastric cancer cells.c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors.Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.Role of E3 ubiquitin ligases in lung cancer.The role and therapeutic implications of RING-finger E3 ubiquitin ligases in hepatocellular carcinoma.Expression and mutational analysis of c-CBL and its relationship to the MET receptor in head and neck squamous cell carcinoma.Cell regulation by phosphotyrosine-targeted ubiquitin ligases.PCSF: An R-package for network-based interpretation of high-throughput data.Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL.Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers.Functional variants in DCAF4 associated with lung cancer risk in European populations.Cool-1-mediated inhibition of c-Cbl modulates multiple critical properties of glioblastomas, including the ability to generate tumors in vivo.Ubiquitination and the Regulation of Membrane Proteins.Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer.CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2.CBL enhances breast tumor formation by inhibiting tumor suppressive activity of TGF-β signaling.Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer.New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma.

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P2860

CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.

http://www.wikidata.org/entity/Q33528991

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

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CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

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CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

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type

label

CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

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CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

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CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

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prefLabel

CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

@ast

CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

@en

CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

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JOURNAL.PONE.0008972

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CBL is frequently altered in l ...... MET and EGFR tyrosine kinases.

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Essam El-Hashani

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Fang-Yi Lo

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Gustavo Cervantes

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Han-Shui Hsu

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Kenan Onel

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Martin Sattler

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Matthew Robinson

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Rajani Kanteti

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Rifat Hasina

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Sapana Vora

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P2860

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

Somatic mutations affect key pathways in lung adenocarcinoma

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

cbl-b inhibits epidermal growth factor receptor signaling

Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

Drosophila cbl is essential for control of cell death and cell differentiation during eye development

The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system

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e8972

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10.1371/JOURNAL.PONE.0008972

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1

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Everett E Vokes

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2010-01-29T00:00:00Z

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41401416

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20126411

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2813301

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