Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding. - Wikidata - awgldk - TriplyDB

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

http://www.wikidata.org/entity/Q33556083

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Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.Bactericidal activities of GM flax seedcake extract on pathogenic bacteria clinical strains Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions Single-Molecule Observation of DNA Replication Repair Pathways in E. coli.Mechanisms of drug resistance: quinolone resistance.Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.Mechanism of quinolone action and resistance.Squaring up to DNA: pentapeptide repeat proteins and DNA mimicry.Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.In Vitro Activity of Gepotidacin, a Novel Triazaacenaphthylene Bacterial Topoisomerase Inhibitor, against a Broad Spectrum of Bacterial Pathogens.Detection of a Novel gyrB Mutation Associated With Fluoroquinolone-Nonsusceptible Salmonella enterica serovar Typhimurium Isolated From a Bloodstream Infection in Ghana.Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida.Identification of Potential Therapeutics to Conquer Drug Resistance in Salmonella typhimurium: Drug Repurposing Strategy.Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex.The Global Regulatory Cyclic AMP Receptor Protein (CRP) Controls Multifactorial Fluoroquinolone Susceptibility in Salmonella enterica Serovar Typhimurium.Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms.Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus.Characterization and Genomic Analysis of Quinolone-Resistant Delftia sp. 670 Isolated from a Patient Who Died from Severe Pneumonia.Double-Serine Fluoroquinolone Resistance Mutations Advance Major International Clones and Lineages of Various Multi-Drug Resistant Bacteria.Drug repurposing: An approach to tackle drug resistance in S. typhimurium.Fluoroquinolone-Gyrase-DNA Cleaved Complexes.Fluoroquinolones as imaging agents for bacterial infection.Total synthesis of albicidin: a lead structure from Xanthomonas albilineans for potent antibacterial gyrase inhibitors.Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.Antibacterial activity of enrofloxacin and ciprofloxacin derivatives of β-octaarginine.Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin-Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity.Our Evolving Understanding of the Mechanism of Quinolones.Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules.

P2860

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P2860

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

http://www.wikidata.org/entity/Q33556083

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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JBC.M113.529164

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Journal of Biological Chemistry

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

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Arkady Mustaev

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Gan Luan

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Hiroshi Hiasa

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James M Berger

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Karl Drlica

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Kevin R Marks

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Lisa M Oppegard

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Muhammad Malik

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Natalia Kurepina

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Robert J Kerns

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P2860

DNA T OPOISOMERASES : Structure, Function, and Mechanism

Cellular roles of dna topoisomerases: a molecular perspective

Targeting DNA topoisomerase II in cancer chemotherapy

Structural basis of gate-DNA breakage and resealing by type II topoisomerases

Structural basis for gate-DNA recognition and bending by type IIA topoisomerases

Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function

Type IIA topoisomerase inhibition by a new class of antibacterial agents

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

Crystal structure of the breakage-reunion domain of DNA gyrase

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10.1074/JBC.M113.529164

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18

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289

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2014-02-04T00:00:00Z

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