Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents. - Wikidata - awgldk - TriplyDB

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.

http://www.wikidata.org/entity/Q33566440

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A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo Proinflammatory role for let-7 microRNAS in experimental asthma Splicing therapy for neuromuscular disease Role of CEACAM1 and CEACAM20 in an in vitro model of prostate morphogenesis Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing The crystal structure of an 'All Locked' nucleic acid duplex Targeting Microtubules for Wound Repair Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs Silencing disease genes in the laboratory and the clinic Delivery is key: lessons learnt from developing splice-switching antisense therapies From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro.Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1alpha-oligonucleotide.Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice.Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model RNAi and small interfering RNAs in human disease therapeutic applications.Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates Inhibition of cell division induced by external guide sequences (EGS Technology) targeting ftsZ Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.Internalization of Locked Nucleic Acids/DNA Hybrid Oligomers into Escherichia coli.Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates.High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines.Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes.Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells.Electroporation and microinjection successfully deliver single-stranded and duplex DNA into live cells as detected by FRET measurements.Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection.Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.Short antisense-locked nucleic acids (all-LNAs) correct alternative splicing abnormalities in myotonic dystrophy.Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma.Stabilization of expanded (CTG)•(CAG) repeats by antisense oligonucleotides.Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides.Inhibition of human immunodeficiency virus replication by cell membrane-crossing oligomers Transcriptome dynamics of the microRNA inhibition response.mRNA fragments in in vitro culture media are associated with bovine preimplantation embryonic development.MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice.In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.Ca2+ enrichment in culture medium potentiates effect of oligonucleotides Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers.Male fertility status is associated with DNA methylation signatures in sperm and transcriptomic profiles of bovine preimplantation embryos Short-interference RNAs: becoming medicines.

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Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.

http://www.wikidata.org/entity/Q33566440

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Efficient gene silencing by de ...... sted by transfection reagents.

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Efficient gene silencing by de ...... sted by transfection reagents.

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Efficient gene silencing by de ...... sted by transfection reagents.

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Efficient gene silencing by de ...... sted by transfection reagents.

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Efficient gene silencing by de ...... sted by transfection reagents.

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Nucleic Acids Research

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Efficient gene silencing by de ...... sted by transfection reagents.

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Anatoliy Voskresenskiy

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Anja Høg

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C A Stein

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Daniella Castanotto

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Harris S Soifer

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Henrik Ørum

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J Bo Hansen

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Jesper Worm

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Johnathan Lai

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Luba Benimetskaya

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P2860

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

Disruption of GW bodies impairs mammalian RNA interference

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides

Interactions of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes).

Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity.

G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis

Site and mechanism of antisense inhibition by C-5 propyne oligonucleotides.

Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus.

Telomerase targeted oligonucleotide thio-phosphoramidates in T24-luc bladder cancer cells.

Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells.

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10.1093/NAR/GKP841

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1

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38

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38034384

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19854938

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2800216

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