Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia. - Wikidata - awgldk - TriplyDB

Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.

Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.

http://www.wikidata.org/entity/Q33573339

about

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1.Mutations in VRK1 associated with complex motor and sensory axonal neuropathy plus microcephaly.Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells Large scale genome-wide association and LDLA mapping study identifies QTLs for boar taint and related sex steroids VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells.Exploring Supernumeraries - A New Marker for Screening of B-Chromosomes Presence in the Yellow Necked Mouse Apodemus flavicollis HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence.Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1.Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo.Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.LRRK2 Phosphorylation.Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals.RHEB1 insufficiency in aged male mice is associated with stress-induced seizures.Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells

P2860

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P2860

Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.

http://www.wikidata.org/entity/Q33573339

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@ast

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@en

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@nl

type

label

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@ast

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@en

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@nl

prefLabel

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@ast

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@en

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@nl

P1433

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P2860

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P356

BIOLREPROD.109.079095

P1433

Biology of Reproduction

P1476

Mice deficient in the serine/t ...... ressive loss of spermatogonia.

@en

P2093

Jill K Lindgren

http://www.w3.org/2001/XMLSchema#string

Matthew S Wiebe

http://www.w3.org/2001/XMLSchema#string

Paula Traktman

http://www.w3.org/2001/XMLSchema#string

R Jeremy Nichols

http://www.w3.org/2001/XMLSchema#string

Tyler P Molitor

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of three paralogous members of the Mammalian vaccinia related kinase family

c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)

The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus

Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation

Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells

Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK

Essential role of PDK1 in regulating cell size and development in mice

P304

182-193

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scholarly article

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10.1095/BIOLREPROD.109.079095

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P433

1

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82

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2009-08-19T00:00:00Z

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26756492

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19696012

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P932

2802121

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