The major adduct of the antitumor drug cis-diamminedichloroplatinum(II) with DNA bends the duplex by approximately equal to 40 degrees toward the major groove.
about
Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatinCurved DNA without A-A: experimental estimation of all 16 DNA wedge anglesIsolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II)Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplexChiral discrimination in platinum anticancer drugs.Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)].Crystal lattice packing is important in determining the bend of a DNA dodecamer containing an adenine tractAnalysis of structural flexibility of damaged DNA using thiol-tethered oligonucleotide duplexesReplication protein A (RPA) binding to duplex cisplatin-damaged DNA is mediated through the generation of single-stranded DNA.Prognostic and predictive factors in patients with metastatic or recurrent cervical cancer treated with platinum-based chemotherapy.A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumorsBiological properties of single chemical-DNA adducts: a twenty year perspectiveSingle d(ApG)/cis-diamminedichloroplatinum(II) adduct-induced mutagenesis in Escherichia coli.Diepoxybutane interstrand cross-links induce DNA bending.Lesion selectivity in blockage of lambda exonuclease by DNA damage.Cisplatin-DNA damage recognition proteins in human tumour extracts.Cisplatin damage overrides the predefined rotational setting of positioned nucleosomes.Nucleotide excision repair in Escherichia coliPhotoaffinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA.Possible catalytic activity of DNA in the reaction between the antitumor drug cis-diamminedichloroplatinum(II) and the intercalator N-methyl-2,7-diazapyreniumDNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent.Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes.A single d(GpG) cisplatin adduct on the estrogen response element decreases the binding of the estrogen receptor.Biophysical analysis of DNA modified by 1,2-diaminocyclohexane platinum(II) complexes.Distortions induced in double-stranded oligonucleotides by the binding of cis- or trans-diammine-dichloroplatinum(II) to the d(GTG) sequence.Effect of geometric isomerism in dinuclear platinum antitumour complexes on the rate of formation and structure of intrastrand adducts with oligonucleotides.DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexesStructural study of DNA duplexes containing the (6-4) photoproduct by fluorescence resonance energy transferSuperhelical torsion controls DNA interstrand cross-linking by antitumor cis- diamminedichloroplatinum(II)DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands.Intrastrand cross-links are not formed in the reaction between transplatin and native DNA: relation with the clinical inefficiency of transplatin.Base sequence-independent distorsions induced by interstrand cross-links in cis-diamminedichloroplatinum (II)-modified DNA.Identification of DNA--cisplatin adducts in a blind trial of in situ scanning tunneling microscopyB----Z DNA conformational changes induced by a family of dinuclear bis(platinum) complexes.Interaction of novel bis(platinum) complexes with DNA.Molecular structure of the complex formed between the anticancer drug cisplatin and d(pGpG): C222(1) crystal form.Cell killing of melanoma B16 in vivo by hyperthermia and cytotoxins.DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair.A method for assaying the sensitivity of Drosophila replication checkpoint mutants to anti-cancer and DNA-damaging drugs.Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action.
P2860
Q24562722-D115281A-5DF0-42D3-B316-5D25B29E1989Q24563875-D46DD011-ABE2-4043-BA79-205AD1CEDA33Q24604428-A50A7376-393C-4C41-A2EA-A8D4BC04164EQ24622867-DD2C4C0E-4082-4BB8-8852-5E45119D2EB9Q24812493-54575BAC-8B10-439D-8B11-CB00A28C2579Q24813746-86ADD5EB-9431-4E58-B100-E7993C89625CQ27728505-2F5E8C8F-613D-4DFE-902D-123AC280E493Q28543459-83F59E62-6482-40CD-9353-41C660103808Q30631650-B6EDC079-DADC-45CF-9C4D-63281D2B2D50Q32187309-B6B81744-D80D-487D-8E04-4EFE09363C98Q33575946-7A01FB4E-33DB-487B-9AD9-FB280E709EF1Q33649960-D7562210-E9DC-46C1-B3D6-7BD12FFA0CDBQ33736530-60C640E5-3304-4C68-9846-81B0CDB00A77Q35608561-7477F687-C475-49DF-8CE1-B20329BFD3F7Q35847695-40CADF7A-981E-4F83-B2EB-ECFC6C559EF0Q35976534-3297E187-2E52-4C71-AEEE-F94DEA41DCD8Q36819060-455AC568-E151-419E-9ABE-2B976963EFFDQ37056044-1B979003-5F2C-41EE-9FBC-D54C694B7F27Q37261476-51028F6D-93BF-4683-A254-834AD297B924Q37490248-7B1A07B9-886F-4881-8AC6-6F0D23A43180Q38287679-4E753EBE-511A-4387-B75B-FACB26C73AFEQ38313636-043AD880-95BC-4D35-966B-04E2D5886A9AQ38316074-7A5684D6-1E50-41E4-A89B-0CD1B059D22BQ38330896-CA9A6107-4771-4999-87B8-7B3973D1AC0EQ38339716-A0D01988-EB99-4B67-9B32-71D07807C947Q38347735-68A1A4A6-CFA7-4B85-81C6-135F67CDC5AEQ38348382-3ACFF24E-44F6-432A-94DA-2C80F4EAA4A7Q39516136-185E854D-2494-469C-9AB3-4528C61C8C43Q39717774-2192B8FF-98DC-412C-B801-068D16A4763EQ40161916-51340B24-F982-4406-8B0C-2B6129ED004EQ40394674-D95BC6DE-F9C5-4ACC-B548-3FF7B7C80FB4Q40401317-14B3B85E-D852-44BB-9B0D-679753255933Q40412109-86C724B0-35D4-4EDD-8C9F-590D905D18D0Q40421652-21236E7A-F12B-4393-B049-72571E541692Q40539582-7AFD6ACF-9E2F-46F3-A124-158FCB23C77BQ43547500-3FBCD391-5F8D-414A-88B5-F91BB46A7052Q43872012-80EEC3DD-B456-4E54-BBEA-994F98622C6AQ44133887-4437A994-7536-44A1-9786-A8636EC2208FQ44204833-E4FFA73A-FB30-4392-BD95-95565CC5B0F6Q44582569-60680D9C-1A08-4FE7-8274-1D70B8B368E8
P2860
The major adduct of the antitumor drug cis-diamminedichloroplatinum(II) with DNA bends the duplex by approximately equal to 40 degrees toward the major groove.
description
1988 nî lūn-bûn
@nan
1988 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
name
The major adduct of the antitumor drug cis-diamminedichloroplatinum
@nl
The major adduct of the antitu ...... grees toward the major groove.
@ast
The major adduct of the antitu ...... grees toward the major groove.
@en
type
label
The major adduct of the antitumor drug cis-diamminedichloroplatinum
@nl
The major adduct of the antitu ...... grees toward the major groove.
@ast
The major adduct of the antitu ...... grees toward the major groove.
@en
prefLabel
The major adduct of the antitumor drug cis-diamminedichloroplatinum
@nl
The major adduct of the antitu ...... grees toward the major groove.
@ast
The major adduct of the antitu ...... grees toward the major groove.
@en
P2093
P2860
P356
P1476
The major adduct of the antitu ...... grees toward the major groove.
@en
P2093
D M Crothers
S J Lippard
P2860
P304
P356
10.1073/PNAS.85.12.4158
P407
P577
1988-06-01T00:00:00Z