Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.
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The path for metal complexes to a DNA targetStructural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4The major adduct of the antitumor drug cis-diamminedichloroplatinum(II) with DNA bends the duplex by approximately equal to 40 degrees toward the major groove.Alkylating agents and immunotoxins exert synergistic cytotoxic activity against ovarian cancer cells. Mechanism of action.Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancerIncision of DNA-protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair.Unusual DNA binding modes for metal anticancer complexes.Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli.Resistance to platinum-based chemotherapy in lung cancer cell lines.Nanocarriers for delivery of platinum anticancer drugs.Monoclonal antibodies to DNA modified with cis- or trans-diamminedichloroplatinum(II).Endocytic recycling compartments altered in cisplatin-resistant cancer cells.An NMR study of [d(CGCGAATTCGCG)]2 containing an interstrand cross-link derived from a distamycin-pyrrole conjugateSpectrum of cisplatin-induced mutations in Escherichia coli.Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II).Replication-competent herpes simplex virus vector G207 and cisplatin combination therapy for head and neck squamous cell carcinoma.Optimizing Liposomal Cisplatin Efficacy through Membrane Composition Manipulations.In vitro platinum drug chemosensitivity of human cervical squamous cell carcinoma cell lines with intrinsic and acquired resistance to cisplatin.Exposure of human ovarian carcinoma to cisplatin transiently sensitizes the tumor cells for liposome-mediated gene transfer.Induction of the growth arrest and DNA damage-inducible gene GADD153 by cisplatin in vitro and in vivo.Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditionsMolecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells.Cisplatin induces loop structures and condensation of single DNA molecules.Reaction of nucleic acids and cis-diamminedichloroplatinum(II) in the presence of intercalating agents.Organic cation transporters are determinants of oxaliplatin cytotoxicity.Novel strategies for reversing platinum resistance.Protected Graft Copolymer (PGC) in Imaging and Therapy: A Platform for the Delivery of Covalently and Non-Covalently Bound Drugs.Extracting physical chemistry from mechanics: a new approach to investigate DNA interactions with drugs and proteins in single molecule experiments.Fertility preservation option in young women with ovarian cancer.Comparison of the cytotoxic effects of Juniperus sabina and Zataria multiflora extracts with Taxus baccata extract and Cisplatin on normal and cancer cell lines.DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands.Chromosome-protein interactions in polyomavirus virions.Solution structure of a DNA hairpin and its disulfide cross-linked analog.Inactivation of Tetrahymena rRNA self-splicing by cis-platin proceeds through dissociable complexesThe reaction of platinum(II) complexes with DNA. Kinetics of intrastrand crosslink formation in vitro.Interaction of novel bis(platinum) complexes with DNA.The role of the excision-repair enzymes in mutation-induction by cis-Pt(NH3)2Cl2Characterization of the ternary complexes formed in the reaction of cis-diamminedichloroplatinum (II), ethidium bromide and nucleic acids.Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues.
P2860
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P2860
Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Binding of the antitumor drug cis-diamminedichloroplatinum
@nl
Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.
@en
type
label
Binding of the antitumor drug cis-diamminedichloroplatinum
@nl
Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.
@en
prefLabel
Binding of the antitumor drug cis-diamminedichloroplatinum
@nl
Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.
@en
P1476
Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.
@en
P2093
S J Lippard
P304
P356
10.1016/0304-419X(85)90001-0
P577
1985-01-01T00:00:00Z