Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice

Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice

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http://www.wikidata.org/entity/Q33590493

Q33590493

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TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities AAV-mediated administration of myostatin pro-peptide mutant in adult Ldlr null mice reduces diet-induced hepatosteatosis and arteriosclerosis Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switch Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload.Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease.Reduced estradiol-induced vasodilation and poly-(ADP-ribose) polymerase (PARP) activity in the aortas of rats with experimental polycystic ovary syndrome (PCOS).Blockade of TGF-β 1 signalling inhibits cardiac NADPH oxidase overactivity in hypertensive rats.Fibrocytes: emerging effector cells in chronic inflammation Prevention of TGFβ induction attenuates angII-stimulated vascular biglycan and atherosclerosis in Ldlr-/- mice Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress.Mast cell chymase and tryptase as targets for cardiovascular and metabolic diseases.Transforming growth factor-β and atherosclerosis: interwoven atherogenic and atheroprotective aspects.ROS and RNS signaling in heart disorders: could antioxidant treatment be successful?Oxidized LDL, LOX-1 and atherosclerosis.PKCδ phosphorylation is an upstream event of GSK3 inactivation-mediated ROS generation in TGF-β1-induced senescence.Salvianolate inhibits reactive oxygen species production in H(2)O(2)-treated mouse cardiomyocytes in vitro via the TGFβ pathway.The immunology of atherosclerosis.Association of transforming growth factor-β1 polymorphisms with the risk of chronic kidney diseases.Occlusal disharmony accelerates the initiation of atherosclerosis in apoE knockout rats.Thermodynamic Aspects and Reprogramming Cellular Energy Metabolism during the Fibrosis Process.Growth differentiation factor 15 impairs aortic contractile and relaxing function through altered caveolar signaling of the endothelium.Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model.

P2860

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P2860

Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice

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