A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.
about
Warburg effect and translocation-induced genomic instability: two yeast models for cancer cellsDNA polymerase ε and its roles in genome stabilityStructural insights into eukaryotic DNA replicationDNA polymerase delta in DNA replication and genome maintenanceAntimutator variants of DNA polymerasesA Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iotaGermline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancersDNA replication fidelity and cancerDNA replication error-induced extinction of diploid yeastGenome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminaseHypothesis driven single nucleotide polymorphism search (HyDn-SNP-S).Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variantMutator suppression and escape from replication error-induced extinction in yeastA novel evolutionary strategy revealed in the phaeoviruses.Reverse genetics in eukaryotes.Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelityPools and Pols: Mechanism of a mutator phenotype.The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder.A substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site.DNA polymerases and cancer.DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor HeterogeneityNucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells.Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading.Comprehensive Analysis of Hypermutation in Human Cancer.Hybridization alters spontaneous mutation rates in a parent-of-origin-dependent fashion in Arabidopsis.CRIMEtoYHU: a new web tool to develop yeast-based functional assays for characterizing cancer-associated missense variants.Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae.Mutational signatures and mutable motifs in cancer genomes.
P2860
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P2860
A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A cancer-associated DNA polyme ...... crease in genomic instability.
@ast
A cancer-associated DNA polyme ...... crease in genomic instability.
@en
type
label
A cancer-associated DNA polyme ...... crease in genomic instability.
@ast
A cancer-associated DNA polyme ...... crease in genomic instability.
@en
prefLabel
A cancer-associated DNA polyme ...... crease in genomic instability.
@ast
A cancer-associated DNA polyme ...... crease in genomic instability.
@en
P2093
P2860
P356
P1476
A cancer-associated DNA polyme ...... crease in genomic instability.
@en
P2093
Danielle L Daee
Polina V Shcherbakova
Tony M Mertz
P2860
P304
P356
10.1073/PNAS.0907526106
P407
P577
2009-12-04T00:00:00Z