Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity
about
A panoply of errors: polymerase proofreading domain mutations in cancerYeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrationsNormally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variantProcessing ribonucleotides incorporated during eukaryotic DNA replication.dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Pools and Pols: Mechanism of a mutator phenotype.Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.Heterozygous colon cancer-associated mutations of SAMHD1 have functional significanceRisks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor HeterogeneityDeoxyribonucleotide metabolism, mutagenesis and cancer.Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells.POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologiesA Critical Balance: dNTPs and the Maintenance of Genome StabilityReplicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.Role of Ribonucleotide Reductase in Bacillus subtilis Stress-Associated Mutagenesis.Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.CRIMEtoYHU: a new web tool to develop yeast-based functional assays for characterizing cancer-associated missense variants.Specific reverse transcriptase slippage at the HIV ribosomal frameshift sequence: potential implications for modulation of GagPol synthesis.Stimulation of reverse transcriptase generated cDNAs with specific indels by template RNA structure: retrotransposon, dNTP balance, RT-reagent usage.Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae.Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry.Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.Mutational signatures and mutable motifs in cancer genomes.
P2860
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P2860
Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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2015年论文
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2015年论文
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name
Colon cancer-associated mutato ...... increasing its own infidelity
@ast
Colon cancer-associated mutato ...... increasing its own infidelity
@en
type
label
Colon cancer-associated mutato ...... increasing its own infidelity
@ast
Colon cancer-associated mutato ...... increasing its own infidelity
@en
prefLabel
Colon cancer-associated mutato ...... increasing its own infidelity
@ast
Colon cancer-associated mutato ...... increasing its own infidelity
@en
P2093
P2860
P356
P1476
Colon cancer-associated mutato ...... increasing its own infidelity
@en
P2093
Polina V Shcherbakova
Sushma Sharma
Tony M Mertz
P2860
P304
P356
10.1073/PNAS.1422934112
P407
P577
2015-03-31T00:00:00Z