Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation.
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Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosusQuantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation.Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors.Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor IkarosSpatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation.The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.Transcriptional and epigenetic regulation of T-helper lineage specification.Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasisT cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis.Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets.Transcriptional regulatory networks for CD4 T cell differentiation.Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2.CD4⁺ T cells play a crucial role for lenalidomide in vivo anti-tumor activity in murine multiple myeloma.CD44 Reciprocally regulates the differentiation of encephalitogenic Th1/Th17 and Th2/regulatory T cells through epigenetic modulation involving DNA methylation of cytokine gene promoters, thereby controlling the development of experimental autoimmunSilencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells.Decreased STAT5 phosphorylation and GATA-3 expression in NOX2-deficient T cells: role in T helper developmentIkaros limits basophil development by suppressing C/EBP-α expression.From a gene-centric to whole-proteome view of differentiation of T helper cell subsets.Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.Maternal signals for progeny prevention against allergy and asthma.Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production.Association of the IKZF1 5' UTR variant rs1456896 with lupus nephritis in a northern Han Chinese population.Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells.Th17 cells induce a distinct graft rejection response that does not require IL-17A.Checkpoint Inhibition in Myeloma: Opportunities and Challenges
P2860
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P2860
Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Ikaros silences T-bet expressi ...... ng T helper 2 differentiation.
@ast
Ikaros silences T-bet expressi ...... ng T helper 2 differentiation.
@en
type
label
Ikaros silences T-bet expressi ...... ng T helper 2 differentiation.
@ast
Ikaros silences T-bet expressi ...... ng T helper 2 differentiation.
@en
prefLabel
Ikaros silences T-bet expressi ...... ng T helper 2 differentiation.
@ast
Ikaros silences T-bet expressi ...... ng T helper 2 differentiation.
@en
P2093
P2860
P356
P1476
Ikaros silences T-bet expressi ...... ng T helper 2 differentiation.
@en
P2093
Andrew D Wells
Chunxia Chen
Edward J Pearce
Justin Taylor
Lingzhi Ma
Neelanjana Chunder
Rajan M Thomas
P2860
P304
P356
10.1074/JBC.M109.038794
P407
P577
2009-11-18T00:00:00Z