Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends.
about
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.DNA repair pathway selection caused by defects in TEL1, SAE2, and de novo telomere addition generates specific chromosomal rearrangement signatures.Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replicationBreak-induced DNA replicationDNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombinationSgs1 and Exo1 suppress targeted chromosome duplication during ends-in and ends-out gene targeting.The Mph1 helicase can promote telomere uncapping and premature senescence in budding yeast.DNA end resection--unraveling the tail.Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis.Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zetaDifferential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability.Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae.Caffeine inhibits gene conversion by displacing Rad51 from ssDNA.RPA Stabilization of Single-Stranded DNA Is Critical for Break-Induced Replication.Mechanisms of telomere loss and their consequences for chromosome instability.Recombinational repair of radiation-induced double-strand breaks occurs in the absence of extensive resection.Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins.Harnessing mutagenic homologous recombination for targeted mutagenesis in vivo by TaGTEAM.Sgs1 and Mph1 Helicases Enforce the Recombination Execution Checkpoint During DNA Double-Strand Break Repair in Saccharomyces cerevisiaeMapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation.Break-induced replication occurs by conservative DNA synthesisMph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediatesResection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae.Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity.Regulation of telomere addition at DNA double-strand breaks.Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex.Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases.Exonuclease 1 and its versatile roles in DNA repair.The many facets of homologous recombination at telomeres.The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation.Frequent Interchromosomal Template Switches during Gene Conversion in S. cerevisiae.Endogenous Hot Spots of De Novo Telomere Addition in the Yeast Genome Contain Proximal Enhancers That Bind Cdc13Sites of genetic instability in mitosis and cancer.Genetic instability is prevented by Mrc1-dependent spatio-temporal separation of replicative and repair activities of homologous recombination: homologous recombination tolerates replicative stress by Mrc1-regulated replication and repair activitiesPerinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.Cell cycle-dependent spatial segregation of telomerase from sites of DNA damage.Homology Requirements and Competition between Gene Conversion and Break-Induced Replication during Double-Strand Break Repair.
P2860
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P2860
Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Sgs1 and exo1 redundantly inhi ...... ion at broken chromosome ends.
@ast
Sgs1 and exo1 redundantly inhi ...... ion at broken chromosome ends.
@en
type
label
Sgs1 and exo1 redundantly inhi ...... ion at broken chromosome ends.
@ast
Sgs1 and exo1 redundantly inhi ...... ion at broken chromosome ends.
@en
prefLabel
Sgs1 and exo1 redundantly inhi ...... ion at broken chromosome ends.
@ast
Sgs1 and exo1 redundantly inhi ...... ion at broken chromosome ends.
@en
P2093
P2860
P1433
P1476
Sgs1 and exo1 redundantly inhi ...... ion at broken chromosome ends.
@en
P2093
John R Lydeard
Zachary Lipkin-Moore
P2860
P304
P356
10.1371/JOURNAL.PGEN.1000973
P577
2010-05-27T00:00:00Z