Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis - Wikidata - awgldk - TriplyDB

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

http://www.wikidata.org/entity/Q33597162

about

Repurposing metformin: an old drug with new tricks in its binding pockets Fundamentals of cancer metabolism Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules Unexploited Antineoplastic Effects of Commercially Available Anti-Diabetic Drugs Energy disruptors: rising stars in anticancer therapy?Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents Mitochondria in the regulation of innate and adaptive immunity Targeting mitochondria metabolism for cancer therapy On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer New developments in the management of non-small-cell lung cancer, focus on rociletinib: what went wrong?ROS homeostasis and metabolism: a dangerous liason in cancer cells Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells MATE2 Expression Is Associated with Cancer Cell Response to Metformin Metformin as a cellular protector; a synoptic view of modern evidences Assessment of a prognostic model, PSA metrics and toxicities in metastatic castrate resistant prostate cancer using data from Project Data Sphere (PDS)HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors.Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity Metformin and respiratory chain complex I: the last piece of the puzzle?Targeting MYC Dependence by Metabolic Inhibitors in Cancer Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro.Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus.Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism.Attacking the supply wagons to starve cancer cells to death.Syrosingopine sensitizes cancer cells to killing by metformin Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy Four key questions about metformin and cancer.Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth.Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis Combined regimen of photodynamic therapy mediated by Gallium phthalocyanine chloride and Metformin enhances anti-melanoma efficacy Anti-tumor effects of everolimus and metformin are complementary and glucose-dependent in breast cancer cells

P2860

Q22250976-CF0A499F-0353-49E6-A4F3-3F2A515B6783 Q26744062-15E89E2A-C52A-42DB-8E19-ED140E15B037 Q26747742-E7A69F8B-63B8-4927-9220-BD26D8CFFAA1 Q26750845-04D97883-1999-495B-A1F9-FF6E95A2F8E3 Q26771300-413BBD3C-3912-4898-94DC-0B8EDDDA2409 Q26775580-E67821BB-ECDF-4F19-8156-C484F30BC4CB Q26800890-77CC4D69-5027-45FE-A95E-229CAFE36715 Q26992186-AC5B046A-3E24-4ABC-BD54-52B4E48D4717 Q27027219-A81050A2-9BEA-4CFB-98C7-F0441B3276BC Q28072798-2FAF49A0-B777-4643-94AC-CEF40B36FDA9 Q28075511-B94F104A-6FDA-459D-A426-3E922DC96584 Q28075971-D5EFD8C3-DD4F-4F12-A189-640D76076DA3 Q28081657-049686C3-2BF8-43B1-A6CA-E939A8809237 Q28548411-75956340-68DB-4788-8045-5F3275EFD9F1 Q28551227-03F53A95-FC01-42D4-9138-2F3E9F21F40C Q28551723-771F2E1E-032A-4C5C-AF82-EDFE5FDEBECD Q28555000-92064D71-6B1F-4103-8835-020C522C57D7 Q28817196-841E1EEF-FAFA-4B70-A0EB-1E09D89A58C9 Q30000285-BD762352-3008-4936-A473-9CC274B2B7B2 Q30252313-45A4B841-1645-4154-808E-D6C6DB8F8C79 Q30300847-A0A58FBE-B842-4E03-89FC-DB855AB7D201 Q30728294-39CB49A4-3E7E-421C-BF60-3A75E221B7A1 Q30833290-6D1CFD28-855E-47D3-A522-4DFFAEEAFAEC Q33359251-19E4545A-02FE-44CA-B174-F7593A23EF48 Q33608493-7B362D81-D6DA-426F-B0A1-C6CF1AEBA9EB Q33687560-48193480-9CC6-49AB-93A6-A3430C931C16 Q33819586-9F19B92C-324A-4B73-9718-3632C8CE5D11 Q34044149-B977A524-6052-4026-BDB7-2DF26004561A Q34516773-CD70D4DF-333A-43E6-A01C-5F06CB7A879A Q34548130-88961588-07B6-4B7E-9006-D394D2C576DA Q35368220-07B066AB-D0D1-4F04-897E-248656E0DCCC Q35368376-89E79087-915D-49C0-ACB2-E91E956D6EF1 Q35758003-A51ED1D2-C818-4DA9-8012-2FBCA80281C1 Q35908707-1AC3353D-482C-4BEB-A333-651166FFA577 Q36078840-8983DD27-F961-4A91-A82D-FC5D52CF809C Q36099352-2D02D894-276A-418F-8F4F-18BC6DC76328 Q36191986-8001430D-1751-433D-BBD7-EB88AB560736 Q36275299-45D4960F-5CCD-4298-B5EA-45F0FB7D1289 Q36302221-5EFE1065-A0A3-49B1-8F37-BBF17EAE7E4F Q36327268-D642737C-F211-4336-B8DC-0FAF04D41F1B

P2860

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

http://www.wikidata.org/entity/Q33597162

description

2014 nî lūn-bûn

@nan

2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

@ast

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

@en

type

label

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

@ast

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

@en

prefLabel

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

@ast

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

@en

P1433

Q33597162-323CD49E-DFDF-47B1-AF9A-47D925AF18A7

P1476

Q33597162-BAC1653B-26B7-4E32-839A-CF8426A66E86

P2093

Q33597162-0E265CBB-7754-4DA6-96DA-14A20C559485

Q33597162-2E5A5E08-50DB-4A96-BE4E-4A38E9EAD647

Q33597162-43D33221-AEC6-4D40-B73D-D144CD7A6114

Q33597162-767590AF-FC94-48E6-829D-58605188F95E

Q33597162-93A5D63A-3E30-4019-91E8-D42E4089F96B

Q33597162-A0AE0FF8-8742-475F-A01B-9C1FFEEF4FFB

Q33597162-B362AB7C-DCF9-4A73-AD65-F5D99851CD96

Q33597162-D6515AB1-0A15-4E7F-95DF-A92ADD84D79E

P2860

Q33597162-0F63DE37-40F8-4323-9008-FBEB6733BCBA

Q33597162-11868304-35A6-46D5-99CC-149DF967D08F

Q33597162-21BACAF7-AC73-4C85-B728-CE8D607FABB8

Q33597162-297967A4-987E-473C-A3F3-03A47EE5AE5E

Q33597162-2C213F36-C5C8-4F8A-B959-3DFBF215EFD2

Q33597162-2FFB3545-EBBA-4D2E-BE6F-301589E57342

Q33597162-31002842-E400-40AB-8C15-967B5931047D

Q33597162-31B636F5-0CBB-4FF2-B067-23749E5EF16B

Q33597162-3483F63E-DE99-4835-83DB-2DDD488D6020

Q33597162-38EC0CF3-5A39-4473-94A6-15EAC3155FDC

P304

Q33597162-63D3877E-CAA9-4237-9153-9ABFFD499CF2

P31

Q33597162-C05667ED-4334-4E81-8C50-6FC41CFAC738

P356

Q33597162-B20AC64F-47B6-42E8-8150-64FD442CA196

P407

Q33597162-899316D4-32D1-421D-BC8C-1A55B9AF13D6

P478

Q33597162-A5497CAB-631D-486F-BAB7-C6F2015660B1

P50

Q33597162-543EB751-6667-4DB0-8E03-9B517117FEDC

Q33597162-7F58A541-8BD0-458B-9332-BB9648591903

Q33597162-852145E6-DC4B-468E-96DE-9401632CDD74

P577

Q33597162-8ED42207-8EB4-404D-A5BB-302D2940D7A4

P698

Q33597162-B1327FA6-9AD3-40AB-94C2-D28DA07B6A44

P921

Q33597162-82116FDA-5764-4204-8888-4A6C3730693E

Q33597162-cfc901a9-4bd9-f606-8fcb-2ce24a28961f

P932

Q33597162-F83368E6-6615-401A-985F-02C4D1DE8FEB

P356

P1433

P1476

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

@en

P2093

Andrea Glasauer

http://www.w3.org/2001/XMLSchema#string

Elena Anso

http://www.w3.org/2001/XMLSchema#string

Gokhan M Mutlu

http://www.w3.org/2001/XMLSchema#string

Gr Scott Budigner

http://www.w3.org/2001/XMLSchema#string

Navdeep S Chandel

http://www.w3.org/2001/XMLSchema#string

Robert B Hamanaka

http://www.w3.org/2001/XMLSchema#string

Saul Soberanes

http://www.w3.org/2001/XMLSchema#string

William W Wheaton

http://www.w3.org/2001/XMLSchema#string

P2860

Clinical Pharmacokinetics of Metformin

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

Metformin in cancer: translational challenges

Cellular and molecular mechanisms of metformin: an overview

Hypoxia-inducible factors in physiology and medicine

Complex III releases superoxide to both sides of the inner mitochondrial membrane

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

P304

e02242

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.7554/ELIFE.02242

http://www.w3.org/2001/XMLSchema#string

P407

P478

3

http://www.w3.org/2001/XMLSchema#string

P50

Lucas B Sullivan

Samuel E Weinberg

P577

2014-05-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

24843020

http://www.w3.org/2001/XMLSchema#string

P921

P932

4017650

http://www.w3.org/2001/XMLSchema#string