Induction of human gamma globin gene expression by histone deacetylase inhibitors
about
Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiationChemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.Reactivation of developmentally silenced globin genes by forced chromatin looping.Fetal globin induction--can it cure beta thalassemia?Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cellsInduction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.Identification of novel small-molecule inducers of fetal hemoglobin using pharmacophore and 'PSEUDO' receptor models.Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex.Thalidomide induces gamma-globin gene expression through increased reactive oxygen species-mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis.The switch from fetal to adult hemoglobinInduction of human fetal hemoglobin expression by adenosine-2',3'-dialdehyde.The therapeutic uses of chromatin-modifying agents.Regulation of the fetal hemoglobin silencing factor BCL11A.Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway.Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation.Fetal globin gene inducers: novel agents and new potential.Novel approaches to the treatment of sickle cell disease: the potential of histone deacetylase inhibitors.Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders.Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms.Hemoglobin genetics: recent contributions of GWAS and gene editing.Natural Remedies for the Treatment of Beta-Thalassemia and Sickle Cell Anemia-Current Status and Perspectives in Fetal Hemoglobin Reactivation.Modulation of microRNAs expression in hematopoietic stem cells treated with sodium butyrate in inducing fetal hemoglobin expression.Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.Phase 1/2 trial of vorinostat in patients with sickle cell disease who have not benefitted from hydroxyurea.Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells.Extensively self-renewing erythroblasts derived from transgenic β-yac mice is a novel model system for studying globin switching and erythroid maturation.Fetal haemoglobin induction in sickle cell disease.Cancer-specific activation of the survivin promoter and its potential use in gene therapy.Genetic disruption of the KLF1 gene to overexpress the γ-globin gene using the CRISPR/Cas9 system.
P2860
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P2860
Induction of human gamma globin gene expression by histone deacetylase inhibitors
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Induction of human gamma globin gene expression by histone deacetylase inhibitors
@ast
Induction of human gamma globin gene expression by histone deacetylase inhibitors
@en
type
label
Induction of human gamma globin gene expression by histone deacetylase inhibitors
@ast
Induction of human gamma globin gene expression by histone deacetylase inhibitors
@en
prefLabel
Induction of human gamma globin gene expression by histone deacetylase inhibitors
@ast
Induction of human gamma globin gene expression by histone deacetylase inhibitors
@en
P2860
P1433
P1476
Induction of human gamma globin gene expression by histone deacetylase inhibitors
@en
P2093
George Stamatoyannopoulos
P2860
P304
P356
10.1182/BLOOD-2003-02-0478
P407
P50
P577
2003-08-14T00:00:00Z