Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. - Wikidata - awgldk - TriplyDB

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.

http://www.wikidata.org/entity/Q33628389

about

Epigenetic regulation of fetal globin gene expression in adult erythroid cells Anemia: progress in molecular mechanisms and therapies A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2 Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin Kinetic assay shows that increasing red cell volume could be a treatment for sickle cell disease.Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies.Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.Chemical probes targeting epigenetic proteins: Applications beyond oncology.Identification and characterization of small-molecule inducers of fetal hemoglobin.Role of natural product diversity in chemical biology.Reactivation of developmentally silenced globin genes by forced chromatin looping.Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3.Class I HDAC imaging using [ (3)H]CI-994 autoradiography Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation.Diamond Blackfan anemia treatment: past, present, and future.Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.Update on fetal hemoglobin gene regulation in hemoglobinopathies Fetal hemoglobin in sickle cell anemia A functional element necessary for fetal hemoglobin silencing Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells Genetic and proteomic approaches to identify cancer drug targets.HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST)A Novel High-Content Immunofluorescence Assay as a Tool to Identify at the Single Cell Level γ-Globin Inducing Compounds Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors.Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context.EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.The switch from fetal to adult hemoglobin Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.Regulation of the fetal hemoglobin silencing factor BCL11A.Chromatin looping as a target for altering erythroid gene expression Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation.Current management of sickle cell anemia.Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.

P2860

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P2860

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.

http://www.wikidata.org/entity/Q33628389

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Chemical genetic strategy iden ...... argets in sickle cell disease.

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Chemical genetic strategy iden ...... argets in sickle cell disease.

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Chemical genetic strategy iden ...... argets in sickle cell disease.

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Chemical genetic strategy iden ...... argets in sickle cell disease.

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Chemical genetic strategy iden ...... argets in sickle cell disease.

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PNAS.1006774107

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Chemical genetic strategy iden ...... argets in sickle cell disease.

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P2093

Benjamin L Ebert

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Cindy Y Chang

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Daniel J DeAngelo

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Elizabeth Morse

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James E Bradner

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Job Dekker

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Jocelyn Bosco

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John Paul Shen

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Katherine Lin

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Kenneth Ross

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P2860

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

Capturing chromosome conformation

Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma

Developmental and species-divergent globin switching are driven by BCL11A

The active spatial organization of the beta-globin locus requires the transcription factor EKLF

Chemical phylogenetics of histone deacetylases.

Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays.

Management of sickle cell disease.

Induction of human gamma globin gene expression by histone deacetylase inhibitors

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12617-12622

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10.1073/PNAS.1006774107

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28

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107

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Ralph Mazitschek

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2010-06-28T00:00:00Z

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45113566

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20616024

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sickle-cell disease

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2906581

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