FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis. - Wikidata - awgldk - TriplyDB

FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis.

FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis.

http://www.wikidata.org/entity/Q33604706

about

Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus Erythropoietin: new directions for the nervous system Targeting disease through novel pathways of apoptosis and autophagy Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy Oxidative stress: Biomarkers and novel therapeutic pathways.Diabetes mellitus: channeling care through cellular discovery FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling.Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation.Wnt1, FoxO3a, and NF-kappaB oversee microglial integrity and activation during oxidant stress.Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways.PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection Novel avenues of drug discovery and biomarkers for diabetes mellitus.EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3β, and β-catenin to foster vascular integrity during experimental diabetes.Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress.Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders.Translating cell survival and cell longevity into treatment strategies with SIRT1 Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia.Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy.Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1 Forkhead transcription factors: new considerations for alzheimer's disease and dementia.Tanshinol attenuates the deleterious effects of oxidative stress on osteoblastic differentiation via Wnt/FoxO3a signaling.Targeting erythropoietin for chronic neurodegenerative diseases.Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders.Malibatol A enhances alternative activation of microglia by inhibiting phosphorylation of Mammalian Ste20-like kinase1 in OGD-BV-2 cells.NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II Emodin-induced microglial apoptosis is associated with TRB3 induction.A sub-pathway-based approach for identifying drug response principal network.Forkhead Transcription Factors: Formulating a FOXO Target for Cognitive Loss.Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors.The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders.FoxO proteins in the nervous system.

P2860

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P2860

FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis.

http://www.wikidata.org/entity/Q33604706

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

FoxO3a governs early microglia ...... ing oxidant induced apoptosis.

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FoxO3a governs early microglia ...... ing oxidant induced apoptosis.

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type

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FoxO3a governs early microglia ...... ing oxidant induced apoptosis.

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FoxO3a governs early microglia ...... ing oxidant induced apoptosis.

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FoxO3a governs early microglia ...... ing oxidant induced apoptosis.

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Current neurovascular research

P1476

FoxO3a governs early microglia ...... ing oxidant induced apoptosis.

@en

P2093

Jinling Hou

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Kenneth Maiese

http://www.w3.org/2001/XMLSchema#string

Yan Chen Shang

http://www.w3.org/2001/XMLSchema#string

Zhao Zhong Chong

http://www.w3.org/2001/XMLSchema#string

P2860

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK

Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases

FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells

AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9

Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout the life span

Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine.

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition

Identification of the prosurvival activity of nerve growth factor on cardiac myocytes.

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10.2174/156720209789630302

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4

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