Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence. - Wikidata - awgldk - TriplyDB

Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence.

Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence.

http://www.wikidata.org/entity/Q33604982

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Neurobiology of opioid dependence in creating addiction vulnerability Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics Opioid-induced central immune signaling: implications for opioid analgesia Heroin use is associated with suppressed pro-inflammatory cytokine response after LPS exposure in HIV-infected individuals Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae Toll-like receptor 4 and comorbid pain in Interstitial Cystitis/Bladder Pain Syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model.Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine.BK channels in microglia are required for morphine-induced hyperalgesia.Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.Therapies in early development for the treatment of opiate addiction.Opioid adjuvant strategy: improving opioid effectiveness.Neurobiological Effects of Morphine after Spinal Cord Injury.Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids.Morphine enhances IL-1β release through toll-like receptor 4-mediated endocytic pathway in microglia.Opioid misuse in gastroenterology and non-opioid management of abdominal pain.Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord.Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation.A Pharmacological Rationale to Reduce the Incidence of Opioid Induced Tolerance and Hyperalgesia: A Review.

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P2860

Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence.

http://www.wikidata.org/entity/Q33604982

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2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Toll-like receptor 4 mutant an ...... esia, and physical dependence.

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Toll-like receptor 4 mutant an ...... esia, and physical dependence.

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Brian Milne

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Catherine M Cahill

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Chris J B Nicol

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Graham Skelhorne-Gross

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Heather Leduc-Pessah

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Theresa Alexandra Mattioli

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Tuan Trang

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P2860

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Stereoselective action of (+)-morphine over (-)-morphine in attenuating the (-)-morphine-produced antinociception via the naloxone-sensitive sigma receptor in the mouse

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

Morphine enhances microglial migration through modulation of P2X4 receptor signaling

Toll-like receptor 9 is required for opioid-induced microglia apoptosis.

Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation.

The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy.

Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2.

Animal models of nociception.

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e97361

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